Fig. 7From: SMAD1 as a biomarker and potential therapeutic target in drug-resistant multiple myelomaProposed model for the effects of SMAD1 on apoptosis and cell growth in MM. SMAD1 inhibition affects growth through two axes: it blocks the cell cycle. Through ID1-p21/p27 and cell survival through NF-kB-TNFAIP8, the latter of which is critical in the context of drug resistant MMBack to article page