From: The emerging role of RNA N6-methyladenosine methylation in breast cancer
Types | Component | Regulation | Sources | Subtypes | Related targets | Key biological function | Ref. |
---|---|---|---|---|---|---|---|
Writers | MELLT3 | Up-regulation | MCF-7 MDA-MB-231 MDA-MB-453 MDA-MB-468 MCF-10A | Luminal A Basal Her2+ Basal Basal | let-7 g, Bcl-2 | 1.METTL3 accelerate cell proliferation and migration. 2.Knockdown METTL3 reduce proliferation and accelerate cell apoptosis. | |
Down | MDA-MB-231 MDA-MB-468 | Basal Basal | COL3A1 | METTL3 overexpression suppress migration, invasion, and adhesion. | [24] | ||
RBM15 | Uncertain | MCF-7, T47D | Luminal A | BAP1 | RBM15 mediate cell growth and invasion. | [25] | |
WTAP | Down | MCF-7 MDA-MB-231 | Luminal A Basal | KGF, Erk1, Erk2 | 1.WTAP mediate proliferation and motility of breast cancer cells. 2.Prompt cell motility and invasion. | ||
METTL14 | Up-regulation | BT549 T47D, MCF-7 SKBR3 MDA-MB-231 MDA-MB-436 | Basal Luminal A Her2+ Basal Basal | CXCR4, CYP1B1, Hsa-miR-146a-5p | 1.LNC942 prompt cell proliferation and growth by targeting METTL14. 2.METTL14 effect hsa-miR-146a-5p expression and promote the migration and invasion, little effect on cell proliferation. | ||
Down | MDA-MB-231 | Basal | – | Over expression of METTL14 remarkably suppressed cell growth and migration. | [26] | ||
KIAA1429 | Up-regulation | MCF-7 SUM1315 MDA-MB-231 | Luminal A Basal Basal | CDK1 | KIAA1429 prompt proliferation, colony formation, migration, invasion, and metastasis. | ||
Down | Breast cancer | Her2+ | – | – | [26] | ||
CBLL1 | Up-regulation | MCF-7 Hakai cells | Luminal A Luminal | ERα | CBLL1 inhibit cell proliferation and migration. | ||
Erasers | FTO | Up-regulation | 4 T1 MCF-7 SKBR-3 MDA-MB-231 MDA-MB-453 | Basal Luminal A Her2+ Basal Her2+ | BNIP, FTO/miR-181b-3p/ARL5B pathway | 1.Promotes tumor growth and metastasis by inhibiting BNIP3. 2.Promote cell invasion and migration in vitro. 3.Promotes development and aggressiveness of breast cancer. | |
ALKBH5 | Up-regulation | MCF-7, T47D SUM-159 MDA-MB-231 MDA-MB-435 | Luminal A Basal Basal HER2+ | NANOG | 1.HIF1α and HIF2α prompt ALKBH5expession. 2.ALKBH5 is required for breast cancer tumorigenicity and lung metastasis. 3.ALKBH5 knockdown to increased proliferation and migration. | ||
Readers | FMR1 | Up-regulation | 4 T1 | Basal | E-cadherin, Vimentin | 1.FMR1 prompt tumor growth, metastasis and cell invasion. 2.CHIP up regulates FMR1 expression. | |
FXR1 | Up-regulation | BT549 MCF-7 MDA-MB-231 | Basal Luminal A Basal | ECT2, PRKCI, Myc | 1.FXR1 prompt cell invasion. | ||
IGF2BP1 | Up-regulation | T47D MDA-MB-231MDA-MB-157 | Luminal A Basal Basal | IGF2, ACTB, MYC, CD44, CTNNB, BTRC, β-catenin | IGF2BP1 inhibit cell proliferation, tumor growth and pulmonary metastatic tumor. | ||
IGF2BP2 | Up-regulation | SKBR3 MCF-7 MDA-MB-231MDA-MB-435MDA-MB-468 LM2-4 cells | Her2+ Luminal A Basal Basal Basal Basal | CTGF, IGF-2, IGF-1, ERK, PI3K/Akt pathways | 1.IGF2BP2 prompt cell migration and reduced cell adhesion by targeting CTGF mRNA. 2.IGF2BP2 stimulate cell proliferation, growth and differentiation. 3.miR-1193 also suppressed IGF2BP2 translation. 4.IGFBP2 mediate endothelial recruitment through IGF1/IGF1R pathways. | ||
IGF2BP2/IGF2BP3 | Up-regulation | MDA-MB-157 MDA-MB-231 MCF-7, T47D BT474 | Basal Basal Luminal A Luminal B | microRNA-200a, CNOT1 | IGF2BP2/IGF2BP3 cooperate increase cell migration and invasion by targeting microRNA-200a. | [57] | |
IGF2BP3 | Up-regulation | T47D, MCF-7 HCC1937 SUM-1315 MDA-MB-231MDA-MB-435 MDA-MB-468 SKBR3 | Luminal A Basal Basal Basal Basal Basal Her2+ | EMT, ABCG, EGFR signaling, CD44/CD44 + Fbs/IGF2 | 1.IGF2BP3 increase cell migration and invasion. 2.IGF2BP3 prompt EMT and Blockade of miR-3614 maturation. | ||
HNRNPC | Up-regulation | T47D MCF-7 MDA-MB-435 | Luminal A Luminal A Basal | IRF3/7, ISGF3, IFNβ | 1.HNRNPC prompt cell proliferation, migration, invasion and metastasis. 2.Repression of HNRNPC arrested the proliferation and tumorigenesis. | ||
HNRNPA2B1 | Up-regulation | MCF-7 MCF-10A MDA-MB-231 LCC9 | Luminal A Basal Basal Luminal | STAT3, ERK1, ERK2 | 1.HNRNPA2B1 prompt in cancer development, progression, gene expression. 2.HNRNPA2B1 associate with endocrine resistance. 3.Knockdown of HNRNPA2B1 inhibit proliferation. | ||
Down | MDA-MB-231 MCF-7 cells | Basal Luminal A | PFN2, Wnt pathway, ERK/MAPK/Twist pathway | HNRNPA2B1 inhibits the growth of xenograft tumours but promotes spontaneous lung metastasis. | [73] | ||
YTHDF1 YTHDF2 | Up-regulation | MCF-7 MDA-MB-231 MDA-MB-468 | Luminal A Basal Basal | – | 1.YTHDF1/2 regulate the expression of YTHDF3. 2.YTHDF1/2 enhance cell proliferation, migration and invasion. | ||
YTHDF3 | Up-regulation | MDA-MB-231 HCC1954 4 T1 | Basal Her2+ Basal | ST6GALNAC5, GJA1, EGFR | 1.YTHDF3 promotes brain endothelial adhesion, extravasation, invasion, angiogenesis, and cell-astrocyte interaction. 2.Knockdown of YTHDF3 significantly decrease brain metastasis in mouse models. 3.miR-106b-5p down regulate the expression of YTHDF3. | ||
eIF3A | Uncertain | MCF-7 ZR-75-1 MDA-MB-231 MDA-MB-453MDA-MB-468 | Luminal A Luminal B Basal Her2+ Basal | 4EBP1, M2 protein | eIF3A facilitate the proliferation or migration. | ||
G3BP1 | Up-regulation | MCF-7 SKBR3 MDA-MB-231 MDA-MB-468 BT549 | Luminal A Her2+ Basal Basal Basal | PMP22, EMT, ZEB1, TGF-b signaling | 1.G3BP1 facilitate tumor invasion and migration. 2.G3BP1 involve in vesicle trafficking. |