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Fig. 2 | Biomarker Research

Fig. 2

From: Immunological and genetic kinetics from diagnosis to clinical progression in chronic lymphocytic leukemia

Fig. 2

PD1+ effector memory CD8+ T cells subsets and co-expression of inhibitory receptors in progressing and non-progressing CLL patients. a Absolute numbers of PD1+ EM and b PD1+ EMRA CD8+ T cells in progressing (left, n = 18) and non-progressing patients (middle, n = 10) at diagnosis and progression or non-progression. Fold change between time points of PD1+ EM and PD1+ EMRA CD8+ cells in progressing and non-progressing patients (right). c Representative viSNE plots of T cell differentiation subsets (naïve: CCR7+CD45RA+; central memory, CM: CCR7+CD45RA; effector memory, EM: CCR7CD45RA and EM CD45RA+, EMRA: CCR7CD45RA+) and PD1 expression in CD4+ and CD8+ T cells at the two time points from one representative patient from each group. d Percentages of EM CD8+ cells co-expressing CD244 and PD1 (n = 12) and e CD160 and PD1 (n = 10). Graphs show mean ± SEM or paired values. (*P < 0.05; **P < 0.01; ***P < 0.001; Wilcoxon matched paired test or Mann-Whitney test)

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