Fig. 1

Workflow of the study. Identification of prognostic/predictive miRNAs in the Regina Elena National Cancer Institute cohort (IRE miRNA_array 60 T), and validation in the TCGA cohort (TCGA miRNA_array 563 T, and TCGA miRNA_seq 499 T) (a). Differential miRNA expression analysis according to disease setting, BRCA 1/2 status, and in tumor versus normal tissue for the IRE cohort (b). TCGA validation of the tumor versus normal dysregulated miRNAs, and identification of prognostic and biological signatures based on their deregulation (c). Abbreviations: EFS = event free survival; OS = overall survival; T = tumor samples. MiRNAs included in the rectangular shape intersect within the same panel. MiRNAs in red color are negatively associated to prognosis and platinum sensitivity, while those in blue color are positively associated with the same outcomes. MiRNAs preceded by a upward arrow are upregulated in cancer tissue with respect to normal tissue, while those preceded by a downward arrow are downregulated