Fig. 3

Strategies to target MARCKS signaling. Schematic depicting the current approaches available to target MARCKS signaling in cancer. Indirect targeting includes inhibitors for PKC and NADPH oxidase (NOX) which induce the phosphorylation of MARCKS. Direct targeting of MARCKS can be performed using small RNAs, peptidomimetics, or alternative strategies as a single agent or in combination with traditional chemotherapy and/or radiotherapy