Skip to main content
Fig. 2 | Biomarker Research

Fig. 2

From: Current views on the genetic landscape and management of variant acute promyelocytic leukemia

Fig. 2

The genetic landscape of RAR-rearranged variant APL. (a) RARA-rearranged variant APL; (b) RARB-rearranged variant APL; (c) RARG-rearranged variant APL. ANK, ankyrin repeats; BBD, BCOR BCL6-binding domain; B1 and 2: B box; CC: coiled-coil domain; DBD, DNA-binding domain; DDD, dimerization/docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase; FIP1: FIP1 binding domain for polymerase; FN3, fibronectin type 3 domain; GLEBS: Gle2/ Rae1-binding sequence; GLFG: Gly-Leu-Phe-Gly repeats; LBD, ligand binding domain; LisH: lissencephaly type-1-like homology motif; LZ, leucine zipper; ND, nucleoplasmin/nucleophosmin domain; NRD, Nuclear reassembly domain; PB1, Phox and Bem1 domain; PHD, plant homedomain finger transcription factor domain; PI, protein interaction domain; POZ: BTB/POZ domain; PQ-rich, proline-glutamine-enriched domain; Pro: proline-rich region; R: RING finger domain; RRM: RNA recognition motif; R1, I-repeat domains; SAD, Spindle association domain; SH2, Src homology 2 (SH2) domain; ZF, zinc finger domain

Back to article page