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Table 1 Multiple functions of METTL3 in human cancer

From: Novel insights into the m6A-RNA methyltransferase METTL3 in cancer

Cancer type Expression Role Targets Biological functions and underlying mechanisms Refs
GC Up Oncogene MYC Promotes tumor progression by enhancing MYC expression [44, 45]
SEC62 Promotes anti-apoptosis by depressing the apoptosis pathway [46]
HDGF Actives aerobic glycolysis by GLUT4 and ENO2 to promote tumor growth [48]
LncRNA LINC00470 Potentiates tumor growth by functional inhibition of PTEN [40]
ZMYM1 Promotes EMT by inhibiting E-cadherin expression [49]
GIF-1 and α-SMA Enhances cell mobility and instant metastasis [43]
ARHGAP5 Enhances chemoradioresistance by stabilizing ARHGAP5 mRNA [41]
Suppressor BATF2 Suppresses tumor progress by inhibiting the ERK pathway [50]
DGCR8 Enhances chemosensitivity to mTOR inhibitor [51]
HCC Up Oncogene SOCS2 Enhances cell proliferation, migration and stemness maintenance [54]
RDM1 Activates the Ras/Raf/ERK pathway to promote tumor progress [55]
Snail Preserves oncogenic properties by up-regulating Snail [56]
miR-6079 and LINC00958 Enhances aerobic glycolysis by activating the mTOR pathway [57, 58]
Suppressor FOXO3 Promotes sorafenib sensitivity, inhibits angiogenesis and autophagy [59]
Gallbladder cancer Up Oncogene miR-92b-3p Inhibits PTEN to promote tumor progression [60]
CRC Up Oncogene SOX2 Promotes self-renewal, cell growth and metastasis [61]
Cyclin E1 Enhances tumor growth [62]
miR-1246 Promotes tumor progression by activating the MAPK pathway [35]
SOCS2 and YPEL5 Promotes tumor progression [31, 63]
HK2 and GLUT1 Accelerates aerobic glycolysis to promote tumor growth [64]
P53 and LGR5 Induces chemotherapeutic resistance [66, 67]
STAT1 and IRF1 Enhances resistance to anti-PD-1 treatment by inhibiting the IFN pathway [68]
PC Up Oncogene miR-25-3p Promotes tumor growth and metastasis by activating the PI3K/AKT pathway [70]
MAPK Induces chemo- and radio-resistance [71]
NPC Up Oncogene ZNF750 Suppresses cell apoptosis by inhibiting the ZNF750-FGF14 pathway [75]
EZH2 Enhances metastasis by up-regulating CDKN1C [74]
Snail Enhances metastasis by increasing the translation of Snail mRNA [77]
OSCC Up Oncogene BMI1 Promotes cell proliferation and metastasis [78]
MYC Promotes tumor progression by increasing the expression of MYC [79]
NSCLC Up Oncogene YAP Stimulates stem cell generation and promotes tumor progression [36]
lncRNA ABHD11-AS1 Enhances aerobic glycolysis to promote tumor progression [80]
PI3K Accelerates tumor growth by activating the AKT pathway [38]
EZH2 Enhances tumor metastasis by inhibiting the expression of EZH2 [80]
miR-143-3p and VASH1 Enhances brain metastasis by eliminating miR-143-3p and VASH1 [81]
autophagy Induces chemotherapeutic resistance [82]
BC Up Oncogene CDCP1 Stimulates cell proliferation and transformation by enhancing CDCP1 expression [88]
ITGA6 Enhances aggressive features of tumor cell by enhancing ITGA6 expression [89]
AFF4 Accelerates tumor growth and invasion by activating MYC [90]
Maintains self-renewal capability of stem cells by activating SOX2 [91]
SETD7 and KLF4 Promotes tumor progression by inhibiting the expression of SETD7 and KLF4 [92]
pri-miR221/222 Induces poor prognosis of BC by functional inhibition of PTEN [34]
PCa Up Oncogene MYC Promotes tumor progression [94]
LEF1 Promotes cell proliferation and metastasis by activating the Wnt pathway [95]
GLI1 Enhances cell growth and survival by activating the SHH pathway [96]
HuR Promotes bone metastasis by enhancing the expression of ITGB1 [97]
GBM Up Oncogene SOX2, SALL2, OLIG2 and POU3F2 Elevates the translation of oncogenes to activate stem-like cell [99]
SOX2 Enhances γ-irradiation resistance by elevating SOX2 expression [100]
Breast cancer Up Oncogene BCL-2, HBXIP and p21 Promotes cell proliferation by enhancing the expression of oncogenes [37, 103, 104]
Pri-miRNA-221-3p Induces adriamycin resistance by facilitating miRNA maturation [105]
AK4 Induces tamoxifen resistance [106]
TNBC Up Suppressor COL3A1 Inhibits cell mobility and ECM adhesion [107]
Ovarian cancer Up Oncogene eIF3c, CSF-1 and FZD10 Promotes tumor progression and poor prognosis [108]
AXL Promotes tumor progression by increasing the translation of AXL [109]
BCL-2 Suppresses cell apoptosis by inhibiting BCL-2 related pathway [110]
miR-126-5p Enhances cell growth, migration and invasion by inhibiting PTEN [111]
Endometrial cancer Up Suppressor AKT regulators Inhibits proliferation and tumorigenicity by inhibiting the AKT pathway [112]
CC Up Oncogene RAB2B Enhances cell proliferation by increasing RAB2B expression [115]
PDK4 and HK2 Enhances aerobic glycolysis to promote tumor growth and chemoresistance [116]
AML Up Oncogene MYC and BCL-2 Promotes cell growth and anti-apoptosis [119]
PTEN Suppresses cell differentiation by inhibiting the AKT pathway
DLBCL Up Oncogene PEDF Promotes cell proliferation by activating the Wnt pathway [123]
HNSCC Up Oncogene lncRNA LNCAROD Promotes cell proliferation and metastasis [124]
TC Up Oncogene HNF1A Enhances migration by activating the Wnt pathway [125]