From: TOX as a potential target for immunotherapy in lymphocytic malignancies
Gene | Biological roles | Roles in cancer | References |
---|---|---|---|
TOX (8q12.1) | Immune system development | Formation of CD8+ T cell exhaustion Inhibited the expression of tumor suppressor genes Inhibited DNA repair | |
TOX2 (20q13.12) | Altering chromatin Promoting TFH cells and NK cell development | Formation of CD8+ T cell exhaustion | |
TOX3 (16q12.1) | Protective factor for neurons | Highly expressed in breast cancers with poor prognosis Highly expressed and serve a tumor-suppressive role in lung cancer | |
TOX4 (14q11.2) | Regulation of cell cycle and fate | Â |