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Table 1 Biological function and the roles of TOX in cancer

From: TOX as a potential target for immunotherapy in lymphocytic malignancies

Gene

Biological roles

Roles in cancer

References

TOX (8q12.1)

Immune system development

Formation of CD8+ T cell exhaustion

Inhibited the expression of tumor suppressor genes

Inhibited DNA repair

[3,4,5,6]

TOX2 (20q13.12)

Altering chromatin

Promoting TFH cells and NK cell development

Formation of CD8+ T cell exhaustion

[4, 7, 8]

TOX3 (16q12.1)

Protective factor for neurons

Highly expressed in breast cancers with poor prognosis

Highly expressed and serve a tumor-suppressive role in lung cancer

[9,10,11,12,13]

TOX4 (14q11.2)

Regulation of cell cycle and fate

 

[14, 15]

  1. TOX Thymocyte selection-associated HMG BOX, TFH cells T follicular helper cells, NK cells Natural killer cells