Fig. 3From: TOX as a potential target for immunotherapy in lymphocytic malignanciesMechanism of TOX function in T cell malignancies. a TOX binds to the repair factors KU70/KU80 and inhibits their function, causing abnormal NHEJ repair, leading to DNA repair inhibition. b TOX and GATA3 facilitate the downstream gene ThPOK to inhibit the expression of RUNX3, which leads to inhibition of its tumor-suppressive functionBack to article page