Fig. 2
From: TOX as a potential target for immunotherapy in lymphocytic malignancies
Schematic model of persistent antigen binding and continuous stimulation of CD8+ T cells. Persistent antigens activate calcium and NFAT signaling, inducing the expression of TOX in the nucleus. TOX remodels the chromatin and increases RNA transcription, which results in an increase in immune checkpoint inhibitor proteins and a decrease in cytokines. APC: antigen presenting cell, TCR: T cell receptor