Skip to main content

Table 3 Summary of the current literature on CHD1L deregulation in solid cancers

From: Diversity roles of CHD1L in normal cell function and tumorigenesis

Cancer

Deregulation

Downstream targets

Phenotypic effect

clinical impact

References

HCC

CHD1L↑

P53↓, p21↓, cyclinE↑, CDK2↑

G1/S phase transition↑, apoptosis↓, proliferation↑

 

[1]

CHD1L↑

Nur77↓

apoptosis↓

 

[18]

CHD1L↑

ARHGEF9↑, Cdc42↑

migration↑, invasion↑, metastasis↑

 

[14]

CHD1L↑

TCTP↑, Cdc25c↓, Cdk1↓

Mitotic progression↑, aneuploidy↑

 

[15]

CHD1L↑

SPOCK1↑, Akt↑

apoptosis↓, invasion↑, metastasis↑

 

[16]

 

CHD1L↑

NTKL↑

cell growth↑, colony formation↑, G1/S transition↑

 

[17]

 

CHD1L↑

NA

 

Poor Prognosis

[21]

Ovarian carcinoma

CHD1L↑

NA

metastasis↑

Prognostic biomarker

[23]

 

CHD1L↑

METAP2↑

invasion↑, metastasis↑

 

[19]

Gastric cancer

CHD1L↑

NA

 

Prognostic biomarker

[22]

Colorectal carcinoma

CHD1L↑

NA

G1/S phase transition↑, apoptosis↓

Prognostic biomarker

[24]

Bladder cancer

CHD1L↑

NA

 

Prognostic biomarker

[25]

Breast cancer

CHD1L↑

NA

 

Prognostic biomarker

[27]

CHD1L↑

MDM2↑, p53↓

Cell cycle↑, cell motility↑

 

[63]

CHD1L↑

PI3K↑, Akt↑, ARK5↑, mTOR↑, MMP2↑, MMP9↑

chemotaxis↑, invasion↑, lung colonization↑

 

[4]

Nasopharyageal carcinoma

CHD1L↑

NA

 

Prognostic biomarker

[27]

Glioma

CHD1L↑

PCNA↑, β-catenin ↓, cyclinD1↑, p53↓, p21↓, cyclinE↑, Cdk2↑, c-capase3↓, Bcl2↑

G1/S phase transition↑, proliferation↑, apoptosis↓, migration↑, invasion↑

 

[64]

NSCLC

CHD1L↑

NA

 

Prognostic biomarker

[12]

CHD1L↑

ABCB1↑, c-Jun↑, NF-kB↑

Cisplatin resistance

 

[66]

Myeloma

CHD1L↑

c-capase9↓, capase3↓

Anti-apoptosis, cell adhesion-mediated drug resistance↑

 

[6]

Pancreatic cancer

CHD1L↑

β-catenin↑

Cell proliferation↑

Poor prognosis

[65]

Esophageal carcinoma

CHD1L↑

NA

proliferation↑, apoptosis↓, metastasis↑, invasion↑

Poor prognosis

[28]

 

CHD1L↑

PI3K/Akt pathway↑

viability↑, apoptosis↓, cisplatin cytotoxicity↓, glycolysis↑

 

[67]

Cholangiocarcinoma

CHD1L↑

hMLH1↓

 

Prognostic biomarker

[103]

 

CHD1L↑

P53↓, cyclinD1↑, CDK2↑, E-cadherin↓, N-cadherin↑, Vimentin↑

EMT↑, G1/S transition↑, Cell proliferation↑

Poor prognosis

[20]