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Table 1 The association of serum concentrations of five selected proteins with the risk of early ESCC

From: Targeted proteomics-derived biomarker profile develops a multi-protein classifier in liquid biopsies for early detection of esophageal squamous cell carcinoma from a population-based case-control study

Protein Controls Cases Crude OR95%CI Adjusted OR(95%CI)
ANXA1 as categorical variable
 First quartile (low) 30 10 1.0 (referent) 1.0 (referent)
 Second quartile 21 19 2.714 (1.071–7.209) 3.364 (0.722–17.31)
 Third quartile 13 27 6.231 (2.351–16.513) 8.128 (1.403–57.13)
 Fourth quartile (high) 6 34 17.00 (5.520–52.359) 31.76 (3.804–355.3)
P for trend    1.1e-07 0.0020
hK8 as categorical variable
 First quartile (low) 9 31 1.0 (referent) 1.0 (referent)
 Second quartile 28 23 0.677 (0.242–1.840) 0.995 (0.197–4.927)
 Third quartile 19 21 0.321 (0.118–0.826) 0.384 (0.067–2.013)
 Fourth quartile (high) 30 10 0.097 (0.033–0.261) 0.034 (0.004–0.200)
P for trend    2.1e-06 0.0002
hK14 as categorical variable
 First quartile (low) 8 32 1.0 (referent) 1.0 (referent)
 Second quartile 13 27 0.519 (0.181–1.418) 0.766 (0.158–3.576)
 Third quartile 20 20 0.250 (0.089–0.655) 0.220 (0.041–1.025)
 Fourth quartile (high) 29 11 0.095 (0.032–0.257) 0.054 (0.008–0.283)
P for trend    2.1e-06 0.0004
VIM as categorical variable
 First quartile (low) 26 14 1.0 (referent) 1.0 (referent)
 Second quartile 25 15 1.114 (0.446–2.794) 6.818 (1.529–35.43)
 Third quartile 11 29 4.896 (1.939–13.11) 14.87 (2.629–107.6)
 Fourth quartile (high) 8 32 7.429 (2.802–21.50) 69.80 (7.297–1145.4)
P for trend    3.8e-06 0.0006
RSPO3 as categorical variable
 First quartile (low) 6 34 1.0 (referent) 1.0 (referent)
 Second quartile 16 24 0.265 (0.084–0.744) 0.250 (0.042–1.312)
 Third quartile 23 17 0.130 (0.041–0.362) 0.064 (0.008–0.359)
 Fourth quartile (high) 25 15 0.106 (0.033–0.295) 0.017 (0.001–0.128)
P for trend    1.2e-05 0.0002
  1. The model contains the five listed serum proteins