Table 2 Summarization of major immune cell subset in AML BM microenvironment and prognosis
From: Single-cell map of diverse immune phenotypes in the acute myeloid leukemia microenvironment
Cluster | Subset | Representative prognostic genes | Prognosis |
|---|---|---|---|
Mast cell | – | Mast cell-gene signature (215 genes) | Good |
DC | CD206+ DC subset | CD206+ DC-gene signature (111 genes), MRC1, TNFSF8 | Poor |
– | CX3CR1, TGFB1, CLEC7A, ITGAX, ITGB2 | Poor | |
Mono/Mac | MARCOhigh subset | MARCOhigh subset-gene signature (203 genes) | Poor |
– | CCL22, CD163, ITGAM, CCL5 | Poor | |
– | MMP9 | Good | |
T | Treg | Treg subset-gene signature (173 genes) | Poor |
Dysfunctional/exhausted T | Dysfunctional/exhausted-gene set (LAG3, TIGIT, CTLA4, HAVCR2, TOX, PDCD1, CD274, PDCD1LG2) | Poor | |
– | CD274, PDCD1LG2, PDCD1, BATF | Poor |