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Table 2 Summarization of major immune cell subset in AML BM microenvironment and prognosis

From: Single-cell map of diverse immune phenotypes in the acute myeloid leukemia microenvironment

Cluster Subset Representative prognostic genes Prognosis
Mast cell Mast cell-gene signature (215 genes) Good
DC CD206+ DC subset CD206+ DC-gene signature (111 genes), MRC1, TNFSF8 Poor
CX3CR1, TGFB1, CLEC7A, ITGAX, ITGB2 Poor
Mono/Mac MARCOhigh subset MARCOhigh subset-gene signature (203 genes) Poor
CCL22, CD163, ITGAM, CCL5 Poor
MMP9 Good
T Treg Treg subset-gene signature (173 genes) Poor
Dysfunctional/exhausted T Dysfunctional/exhausted-gene set (LAG3, TIGIT, CTLA4, HAVCR2, TOX, PDCD1, CD274, PDCD1LG2) Poor
CD274, PDCD1LG2, PDCD1, BATF Poor