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Fig. 3 | Biomarker Research

Fig. 3

From: Single-cell map of diverse immune phenotypes in the acute myeloid leukemia microenvironment

Fig. 3

Dissection and clustering of mature myeloid lineages in AML patients and healthy donors. a UMAP plot of Monocyte/Macrophages from Fig. 1a-represented Mono/Mac cluster. These mature myeloid cells can be divided into 9 subsets without CD14+CD3D+ subset. b Dot plot of differentially key cell-type marker genes. c Heatmap of mean expression of selected cytokine genes in each cell subset. d Proportion of 9 mature myeloid subsets in myeloid population subsets in each AML patient or healthy donor. Only samples of containing ≥20 myeloid cells were represented. e The Kaplan-Meier overall survival curves of TCGA AML patients grouped by specific MACRO+ subset gene sets and myeloid-related genes (CD163, ITGAM, MMP9, and CCL5). + represents censored observations, and P value was calculated by multivariate Cox regression

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