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Fig. 5 | Biomarker Research

Fig. 5

From: LncRNA APCDD1L-AS1 induces icotinib resistance by inhibition of EGFR autophagic degradation via the miR-1322/miR-1972/miR-324-3p-SIRT5 axis in lung adenocarcinoma

Fig. 5

Contribution of SIRT5 to icotinib resistance. a The IC50 value of icotinibinSIRT5 KD-icotinib-resistant cells was determined by MTT assay. b The level of EGFR and p-EGFR in SIRT5 KD-icotinib-resistant cells (PC9/IcoRH and HCC827/IcoRH) was detected by western blot. c-d The apoptosis of SIRT5 KD-icotinib-resistant cells with the treatment of icotinib was analyzed by flow cytometry (c), and apoptosis-related protein PARP was assessed by western blot (d). The mean ± SD of triplicate experiments were plotted, *P < 0.05, **P < 0.01, ***P < 0.001

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Biomarker Research

ISSN: 2050-7771

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