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Table 1 p63 immunostaining in human cancers

From: p63 expression in human tumors and normal tissues: a tissue microarray study on 10,200 tumors

    p63 immunohistochemistry
Tumor type TMA (n) analyzable (n) negative (%) weak (%) moderate (%) strong (%) positive (%)
Tumors of the skin Pilomatrixoma 35 31 77.4 0.0 6.5 16.1 22.6
Basal cell carcinoma 48 45 0.0 0.0 0.0 100.0 100.0
Benign nevus 29 22 100.0 0.0 0.0 0.0 0.0
Squamous cell carcinoma of the skin 50 47 2.1 2.1 0.0 95.7 97.9
Malignant melanoma 48 43 97.7 0.0 0.0 2.3 2.3
Merkel cell carcinoma 46 45 95.6 0.0 4.4 0.0 4.4
Tumors of the head and neck Squamous cell carcinoma of the larynx 100 88 9.1 11.4 15.9 63.6 90.09
Oral squamous cell cancer 50 47 4.3 0.0 4.3 91.5 95.7
Oral squamous cell carcinoma (floor of the mouth) 49 48 0.0 6.3 81.3 12.5 100.0
Pleomorphic adenoma of the parotid gland 15 15 6.7 6.7 6.7 80.0 93.3
Warthin tumor of the parotid gland 127 83 3.6 4.8 2.4 89.2 96.4
Basal cell adenoma of the salivary gland 31 16 81.3 18.8 0.0 0.0 18.8
Tumors of the lung, pleura and thymus Adenocarcinoma of the lung 250 189 87.8 10.6 0.0 1.6 12.2
Squamous cell carcinoma of the lung 6 5 100.0 0.0 0.0 0.0 0.0
Small cell carcinoma of the lung 20 15 80.0 6.7 6.7 6.7 20.0
Malignant mesothelioma 39 39 100.0 0.0 0.0 0.0 0.0
Mesothelioma, other types 76 67 98.5 0.0 1.5 0.0 1.5
Thymoma 29 29 0.0 13.8 20.7 65.5 100.0
Tumors of the female genital tract Squamous cell carcinoma of the vagina 48 35 2.9 2.9 8.6 85.7 97.1
Squamous cell carcinoma of the vulva 50 41 0.0 0.0 7.3 92.7 100.0
Squamous cell carcinoma of the cervix 50 43 2.3 2.3 2.3 93.0 97.7
Adenocarcinoma of the cervix uteri 50 45 80.0 15.6 4.4 0.0 20.0
Endometrioid endometrial carcinoma 236 206 83.5 6.8 9.7 0.0 16.5
Endometrial serous carcinoma 82 60 80.0 11.7 8.3 0.0 20.0
Endometrial malignant mixed Müllerian tumors (MMMT) 48 40 85.0 7.5 5.0 2.5 15.0
Endometrial carcinoma, high grade G3 13 12 66.7 0.0 25.0 8.3 33.3
Endometrial clear cell carcinoma 8 4 100.0 0.0 0.0 0.0 0.0
Endometrial stromal sarcoma 12 12 100.0 0.0 0.0 0.0 0.0
Endometrioid carcinoma of the ovary 115 102 87.3 3.9 8.8 0.0 12.7
Serous carcinoma of the ovary 567 496 92.9 4.2 2.0 0.8 7.1
Mucinous carcinoma of the ovary 97 81 95.1 2.5 2.5 0.0 4.9
Clear cell carcinoma of the ovary 54 48 100.0 0.0 0.0 0.0 0.0
Ovarian malignant mixed Müllerian tumors (MMMT) 47 42 71.4 9.5 19.0 0.0 28.6
Brenner tumor 9 8 25.0 0.0 0.0 75.0 75.0
Tumors of the breast Invasive breast carcinoma of no special type 126 67 97.0 1.5 1.5 0.0 3.0
Lobular carcinoma of the breast 123 97 100.0 0.0 0.0 0.0 0.0
Medullary carcinoma of the breast 15 14 85.7 7.1 7.1 0.0 14.3
Tubular carcinoma of the breast 18 15 100.0 0.0 0.0 0.0 0.0
Mucinous carcinoma of the breast 22 16 100.0 0.0 0.0 0.0 0.0
Phyllodes tumor of the breast 50 36 100.0 0.0 0.0 0.0 0.0
Tumors of the digestive system Adenomatous polyp, low-grade dysplasia 50 41 100.0 0.0 0.0 0.0 0.0
Adenomatous polyp, high-grade dysplasia 50 43 100.0 0.0 0.0 0.0 0.0
Adenocarcinoma of the colon 1882 1743 99.6 0.3 0.1 0.0 0.4
Adenocarcinoma of the small intestine 10 5 100.0 0.0 0.0 0.0 0.0
Gastric adenocarcinoma, diffuse type 176 153 97.4 1.3 0.0 1.3 2.6
Gastric adenocarcinoma, intestinal type 174 151 96.0 0.7 0.7 2.6 4.0
Gastric adenocarcinoma, mixed type 62 56 94.6 1.8 0.0 3.6 5.4
Adenocarcinoma of the esophagus 83 75 97.3 0.0 0.0 2.7 2.7
Squamous cell carcinoma of the esophagus 75 63 3.2 1.6 3.2 92.1 96.8
Squamous cell carcinoma of the anal canal 50 35 0.0 0.0 0.0 100.0 100.0
Cholangiocarcinoma 50 38 86.8 5.3 0.0 7.9 13.2
Hepatocellular carcinoma 50 46 100.0 0.0 0.0 0.0 0.0
Ductal adenocarcinoma of the pancreas 612 489 84.7 5.3 3.7 6.3 15.3
Pancreatic/Ampullary adenocarcinoma 89 64 92.2 1.6 6.3 0.0 7.8
Acinar cell carcinoma of the pancreas 13 12 100.0 0.0 0.0 0.0 0.0
Gastrointestinal stromal tumor (GIST) 50 42 100.0 0.0 0.0 0.0 0.0
Tumors of the urinary system Non-invasive papillary urothelial carcinoma, pTa G2 low grade 177 116 0.0 0.0 2.6 97.4 100.0
Non-invasive papillary urothelial carcinoma, pTa G2 high grade 141 106 0.0 0.9 8.5 90.6 100.0
Non-invasive papillary urothelial carcinoma, pTa G3 187 132 9.8 6.1 15.2 68.9 90.2
Urothelial carcinoma, pT2-4 G3 1117 732 18.9 7.4 9.0 64.8 81.1
Small cell neuroendocrine carcinoma of the bladder 18 18 88.9 5.6 5.6 0.0 11.1
Sarcomatoid urothelial carcinoma 25 18 44.4 11.1 5.6 38.9 55.6
Clear cell renal cell carcinoma 858 509 100.0 0.0 0.0 0.0 0.0
Papillary renal cell carcinoma 255 155 100.0 0.0 0.0 0.0 0.0
Clear cell (tubulo) papillary renal cell carcinoma 21 10 100.0 0.0 0.0 0.0 0.0
Chromophobe renal cell carcinoma 131 96 100.0 0.0 0.0 0.0 0.0
Oncocytoma 177 110 100.0 0.0 0.0 0.0 0.0
Tumors of the male genital organs Adenocarcinoma of the prostate, Gleason 3+3 83 78 100.0 0.0 0.0 0.0 0.0
Adenocarcinoma of the prostate, Gleason 4+4 80 71 100.0 0.0 0.0 0.0 0.0
Adenocarcinoma of the prostate, Gleason 5+5 85 76 100.0 0.0 0.0 0.0 0.0
Adenocarcinoma of the prostate (recurrence) 330 181 100.0 0.0 0.0 0.0 0.0
Small cell neuroendocrine carcinoma of the prostate 17 15 100.0 0.0 0.0 0.0 0.0
Seminoma 50 46 100.0 0.0 0.0 0.0 0.0
Embryonal carcinoma of the testis 50 42 97.6 0.0 2.4 0.0 2.4
Yolk sack tumor 50 38 97.4 0.0 2.6 0.0 2.6
Teratoma 50 33 36.4 9.1 39.4 15.2 63.6
Tumors of endocrine organs Adenoma of the thyroid gland 114 105 100.0 0.0 0.0 0.0 0.0
Papillary thyroid carcinoma 392 363 89.0 6.1 5.0 0.0 11.0
Follicular thyroid carcinoma 158 150 98.7 1.3 0.0 0.0 1.3
Medullary thyroid carcinoma 107 92 100.0 0.0 0.0 0.0 0.0
Anaplastic thyroid carcinoma 45 38 78.9 2.6 2.6 15.8 21.1
Adrenal cortical adenoma 50 47 100.0 0.0 0.0 0.0 0.0
Adrenal cortical carcinoma 26 23 100.0 0.0 0.0 0.0 0.0
Phaeochromocytoma 50 44 100.0 0.0 0.0 0.0 0.0
Appendix, neuroendocrine tumor (NET) 22 10 100.0 0.0 0.0 0.0 0.0
Colorectal, neuroendocrine tumor (NET) 10 7 100.0 0.0 0.0 0.0 0.0
Ileum, neuroendocrine tumor (NET) 49 41 100.0 0.0 0.0 0.0 0.0
Lung, neuroendocrine tumor (NET) 19 12 100.0 0.0 0.0 0.0 0.0
Pancreas, neuroendocrine tumor (NET) 100 83 98.8 1.2 0.0 0.0 1.2
Colorectal, neuroendocrine carcinoma (NEC) 11 7 85.7 14.3 0.0 0.0 14.3
Gallbladder, neuroendocrine carcinoma (NEC) 4 2 100.0 0.0 0.0 0.0 0.0
Pancreas, neuroendocrine carcinoma (NEC) 13 10 100.0 0.0 0.0 0.0 0.0
Tumors of haemotoppitic and lymphoid tissues Hodgkin Lymphoma 45 38 100.0 0.0 0.0 0.0 0.0
Non-Hodgkin Lymphoma 48 45 60.0 22.2 11.1 6.7 40.0
Tumors of soft tissue and bone Tenosynovial giant cell tumor 45 45 100.0 0.0 0.0 0.0 0.0
Granular cell tumor 53 50 100.0 0.0 0.0 0.0 0.0
Leiomyoma 50 47 100.0 0.0 0.0 0.0 0.0
Angiomyolipoma 91 91 100.0 0.0 0.0 0.0 0.0
Angiosarcoma 73 66 97.0 0.0 0.0 3.0 3.0
Dermatofibrosarcoma protuberans 21 21 100.0 0.0 0.0 0.0 0.0
Ganglioneuroma 14 14 100.0 0.0 0.0 0.0 0.0
Kaposi sarcoma 8 8 100.0 0.0 0.0 0.0 0.0
Leiomyosarcoma 87 84 100.0 0.0 0.0 0.0 0.0
Liposarcoma 132 124 100.0 0.0 0.0 0.0 0.0
Malignant peripheral nerve sheath tumor (MPNST) 13 13 100.0 0.0 0.0 0.0 0.0
Myofibrosarcoma 26 26 88.5 11.5 0.0 0.0 11.5
Neurofibroma 117 117 100.0 0.0 0.0 0.0 0.0
Sarcoma, not otherwise specified (NOS) 75 75 92.0 8.0 0.0 0.0 8.0
Paraganglioma 41 41 100.0 0.0 0.0 0.0 0.0
Primitive neuroectodermal tumor (PNET) 23 23 95.7 0.0 0.0 4.3 4.3
Rhabdomyosarcoma 7 7 100.0 0.0 0.0 0.0 0.0
Schwannoma 121 121 100.0 0.0 0.0 0.0 0.0
Synovial sarcoma 12 12 100.0 0.0 0.0 0.0 0.0
Osteosarcoma 43 39 94.9 5.1 0.0 0.0 5.1
Chondrosarcoma 39 27 96.3 3.7 0.0 0.0 3.7