Table 1 p63 immunostaining in human cancers
From: p63 expression in human tumors and normal tissues: a tissue microarray study on 10,200 tumors
| Â | Â | Â | p63 immunohistochemistry | |||||
|---|---|---|---|---|---|---|---|---|
Tumor type | TMA (n) | analyzable (n) | negative (%) | weak (%) | moderate (%) | strong (%) | positive (%) | |
Tumors of the skin | Pilomatrixoma | 35 | 31 | 77.4 | 0.0 | 6.5 | 16.1 | 22.6 |
Basal cell carcinoma | 48 | 45 | 0.0 | 0.0 | 0.0 | 100.0 | 100.0 | |
Benign nevus | 29 | 22 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Squamous cell carcinoma of the skin | 50 | 47 | 2.1 | 2.1 | 0.0 | 95.7 | 97.9 | |
Malignant melanoma | 48 | 43 | 97.7 | 0.0 | 0.0 | 2.3 | 2.3 | |
Merkel cell carcinoma | 46 | 45 | 95.6 | 0.0 | 4.4 | 0.0 | 4.4 | |
Tumors of the head and neck | Squamous cell carcinoma of the larynx | 100 | 88 | 9.1 | 11.4 | 15.9 | 63.6 | 90.09 |
Oral squamous cell cancer | 50 | 47 | 4.3 | 0.0 | 4.3 | 91.5 | 95.7 | |
Oral squamous cell carcinoma (floor of the mouth) | 49 | 48 | 0.0 | 6.3 | 81.3 | 12.5 | 100.0 | |
Pleomorphic adenoma of the parotid gland | 15 | 15 | 6.7 | 6.7 | 6.7 | 80.0 | 93.3 | |
Warthin tumor of the parotid gland | 127 | 83 | 3.6 | 4.8 | 2.4 | 89.2 | 96.4 | |
Basal cell adenoma of the salivary gland | 31 | 16 | 81.3 | 18.8 | 0.0 | 0.0 | 18.8 | |
Tumors of the lung, pleura and thymus | Adenocarcinoma of the lung | 250 | 189 | 87.8 | 10.6 | 0.0 | 1.6 | 12.2 |
Squamous cell carcinoma of the lung | 6 | 5 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Small cell carcinoma of the lung | 20 | 15 | 80.0 | 6.7 | 6.7 | 6.7 | 20.0 | |
Malignant mesothelioma | 39 | 39 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Mesothelioma, other types | 76 | 67 | 98.5 | 0.0 | 1.5 | 0.0 | 1.5 | |
Thymoma | 29 | 29 | 0.0 | 13.8 | 20.7 | 65.5 | 100.0 | |
Tumors of the female genital tract | Squamous cell carcinoma of the vagina | 48 | 35 | 2.9 | 2.9 | 8.6 | 85.7 | 97.1 |
Squamous cell carcinoma of the vulva | 50 | 41 | 0.0 | 0.0 | 7.3 | 92.7 | 100.0 | |
Squamous cell carcinoma of the cervix | 50 | 43 | 2.3 | 2.3 | 2.3 | 93.0 | 97.7 | |
Adenocarcinoma of the cervix uteri | 50 | 45 | 80.0 | 15.6 | 4.4 | 0.0 | 20.0 | |
Endometrioid endometrial carcinoma | 236 | 206 | 83.5 | 6.8 | 9.7 | 0.0 | 16.5 | |
Endometrial serous carcinoma | 82 | 60 | 80.0 | 11.7 | 8.3 | 0.0 | 20.0 | |
Endometrial malignant mixed Müllerian tumors (MMMT) | 48 | 40 | 85.0 | 7.5 | 5.0 | 2.5 | 15.0 | |
Endometrial carcinoma, high grade G3 | 13 | 12 | 66.7 | 0.0 | 25.0 | 8.3 | 33.3 | |
Endometrial clear cell carcinoma | 8 | 4 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Endometrial stromal sarcoma | 12 | 12 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Endometrioid carcinoma of the ovary | 115 | 102 | 87.3 | 3.9 | 8.8 | 0.0 | 12.7 | |
Serous carcinoma of the ovary | 567 | 496 | 92.9 | 4.2 | 2.0 | 0.8 | 7.1 | |
Mucinous carcinoma of the ovary | 97 | 81 | 95.1 | 2.5 | 2.5 | 0.0 | 4.9 | |
Clear cell carcinoma of the ovary | 54 | 48 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Ovarian malignant mixed Müllerian tumors (MMMT) | 47 | 42 | 71.4 | 9.5 | 19.0 | 0.0 | 28.6 | |
Brenner tumor | 9 | 8 | 25.0 | 0.0 | 0.0 | 75.0 | 75.0 | |
Tumors of the breast | Invasive breast carcinoma of no special type | 126 | 67 | 97.0 | 1.5 | 1.5 | 0.0 | 3.0 |
Lobular carcinoma of the breast | 123 | 97 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Medullary carcinoma of the breast | 15 | 14 | 85.7 | 7.1 | 7.1 | 0.0 | 14.3 | |
Tubular carcinoma of the breast | 18 | 15 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Mucinous carcinoma of the breast | 22 | 16 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Phyllodes tumor of the breast | 50 | 36 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Tumors of the digestive system | Adenomatous polyp, low-grade dysplasia | 50 | 41 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 |
Adenomatous polyp, high-grade dysplasia | 50 | 43 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Adenocarcinoma of the colon | 1882 | 1743 | 99.6 | 0.3 | 0.1 | 0.0 | 0.4 | |
Adenocarcinoma of the small intestine | 10 | 5 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Gastric adenocarcinoma, diffuse type | 176 | 153 | 97.4 | 1.3 | 0.0 | 1.3 | 2.6 | |
Gastric adenocarcinoma, intestinal type | 174 | 151 | 96.0 | 0.7 | 0.7 | 2.6 | 4.0 | |
Gastric adenocarcinoma, mixed type | 62 | 56 | 94.6 | 1.8 | 0.0 | 3.6 | 5.4 | |
Adenocarcinoma of the esophagus | 83 | 75 | 97.3 | 0.0 | 0.0 | 2.7 | 2.7 | |
Squamous cell carcinoma of the esophagus | 75 | 63 | 3.2 | 1.6 | 3.2 | 92.1 | 96.8 | |
Squamous cell carcinoma of the anal canal | 50 | 35 | 0.0 | 0.0 | 0.0 | 100.0 | 100.0 | |
Cholangiocarcinoma | 50 | 38 | 86.8 | 5.3 | 0.0 | 7.9 | 13.2 | |
Hepatocellular carcinoma | 50 | 46 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Ductal adenocarcinoma of the pancreas | 612 | 489 | 84.7 | 5.3 | 3.7 | 6.3 | 15.3 | |
Pancreatic/Ampullary adenocarcinoma | 89 | 64 | 92.2 | 1.6 | 6.3 | 0.0 | 7.8 | |
Acinar cell carcinoma of the pancreas | 13 | 12 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Gastrointestinal stromal tumor (GIST) | 50 | 42 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Tumors of the urinary system | Non-invasive papillary urothelial carcinoma, pTa G2 low grade | 177 | 116 | 0.0 | 0.0 | 2.6 | 97.4 | 100.0 |
Non-invasive papillary urothelial carcinoma, pTa G2 high grade | 141 | 106 | 0.0 | 0.9 | 8.5 | 90.6 | 100.0 | |
Non-invasive papillary urothelial carcinoma, pTa G3 | 187 | 132 | 9.8 | 6.1 | 15.2 | 68.9 | 90.2 | |
Urothelial carcinoma, pT2-4 G3 | 1117 | 732 | 18.9 | 7.4 | 9.0 | 64.8 | 81.1 | |
Small cell neuroendocrine carcinoma of the bladder | 18 | 18 | 88.9 | 5.6 | 5.6 | 0.0 | 11.1 | |
Sarcomatoid urothelial carcinoma | 25 | 18 | 44.4 | 11.1 | 5.6 | 38.9 | 55.6 | |
Clear cell renal cell carcinoma | 858 | 509 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Papillary renal cell carcinoma | 255 | 155 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Clear cell (tubulo) papillary renal cell carcinoma | 21 | 10 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Chromophobe renal cell carcinoma | 131 | 96 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Oncocytoma | 177 | 110 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Tumors of the male genital organs | Adenocarcinoma of the prostate, Gleason 3+3 | 83 | 78 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 |
Adenocarcinoma of the prostate, Gleason 4+4 | 80 | 71 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Adenocarcinoma of the prostate, Gleason 5+5 | 85 | 76 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Adenocarcinoma of the prostate (recurrence) | 330 | 181 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Small cell neuroendocrine carcinoma of the prostate | 17 | 15 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Seminoma | 50 | 46 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Embryonal carcinoma of the testis | 50 | 42 | 97.6 | 0.0 | 2.4 | 0.0 | 2.4 | |
Yolk sack tumor | 50 | 38 | 97.4 | 0.0 | 2.6 | 0.0 | 2.6 | |
Teratoma | 50 | 33 | 36.4 | 9.1 | 39.4 | 15.2 | 63.6 | |
Tumors of endocrine organs | Adenoma of the thyroid gland | 114 | 105 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 |
Papillary thyroid carcinoma | 392 | 363 | 89.0 | 6.1 | 5.0 | 0.0 | 11.0 | |
Follicular thyroid carcinoma | 158 | 150 | 98.7 | 1.3 | 0.0 | 0.0 | 1.3 | |
Medullary thyroid carcinoma | 107 | 92 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Anaplastic thyroid carcinoma | 45 | 38 | 78.9 | 2.6 | 2.6 | 15.8 | 21.1 | |
Adrenal cortical adenoma | 50 | 47 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Adrenal cortical carcinoma | 26 | 23 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Phaeochromocytoma | 50 | 44 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Appendix, neuroendocrine tumor (NET) | 22 | 10 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Colorectal, neuroendocrine tumor (NET) | 10 | 7 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Ileum, neuroendocrine tumor (NET) | 49 | 41 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Lung, neuroendocrine tumor (NET) | 19 | 12 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Pancreas, neuroendocrine tumor (NET) | 100 | 83 | 98.8 | 1.2 | 0.0 | 0.0 | 1.2 | |
Colorectal, neuroendocrine carcinoma (NEC) | 11 | 7 | 85.7 | 14.3 | 0.0 | 0.0 | 14.3 | |
Gallbladder, neuroendocrine carcinoma (NEC) | 4 | 2 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Pancreas, neuroendocrine carcinoma (NEC) | 13 | 10 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Tumors of haemotoppitic and lymphoid tissues | Hodgkin Lymphoma | 45 | 38 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 |
Non-Hodgkin Lymphoma | 48 | 45 | 60.0 | 22.2 | 11.1 | 6.7 | 40.0 | |
Tumors of soft tissue and bone | Tenosynovial giant cell tumor | 45 | 45 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 |
Granular cell tumor | 53 | 50 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Leiomyoma | 50 | 47 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Angiomyolipoma | 91 | 91 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Angiosarcoma | 73 | 66 | 97.0 | 0.0 | 0.0 | 3.0 | 3.0 | |
Dermatofibrosarcoma protuberans | 21 | 21 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Ganglioneuroma | 14 | 14 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Kaposi sarcoma | 8 | 8 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Leiomyosarcoma | 87 | 84 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Liposarcoma | 132 | 124 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Malignant peripheral nerve sheath tumor (MPNST) | 13 | 13 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Myofibrosarcoma | 26 | 26 | 88.5 | 11.5 | 0.0 | 0.0 | 11.5 | |
Neurofibroma | 117 | 117 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Sarcoma, not otherwise specified (NOS) | 75 | 75 | 92.0 | 8.0 | 0.0 | 0.0 | 8.0 | |
Paraganglioma | 41 | 41 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Primitive neuroectodermal tumor (PNET) | 23 | 23 | 95.7 | 0.0 | 0.0 | 4.3 | 4.3 | |
Rhabdomyosarcoma | 7 | 7 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Schwannoma | 121 | 121 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Synovial sarcoma | 12 | 12 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
Osteosarcoma | 43 | 39 | 94.9 | 5.1 | 0.0 | 0.0 | 5.1 | |
Chondrosarcoma | 39 | 27 | 96.3 | 3.7 | 0.0 | 0.0 | 3.7 | |