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Table 2 Post-transplant complications

From: Development of acoustically isolated extracellular plasma vesicles for biomarker discovery in allogeneic hematopoietic stem cell transplantation

  # affected patients (pat-ID)
Complicationa Pre/Tx week 1 week 2 week 3 week 4 week 6 week 8 week 10/11 week12
Early infection, neutropenic (week 1–4) 4b (3, 10, 11, 19) 7 (1,2,5, 7,11,12,19) 11 (2,5,6,8,9,11,12,13,16,19,20) 5 (5,9,12,14,16) 2 (5,16)     
Late Infection (≥ week 5)         2 (1,8) 1 (1)
GvHD (all grades)    1 1 2 7 7 7 5
Grade I    1 (2) 1 (2) 2 (1,8) 7 (1,2,4,7,8,9,17) 5 (1,2,6,7,17) 5 (2,4,5,6,7) 4 (2,4,10,18)
Grade II/III        2 (8,19) 2 (8,19) 1 (8)
CMV reactivation       3 (1,4,16) 2 (16,19) 1 (19) 1 (8)
  1. aDefinition of complications: Infection (use of broad spectrum i.v. antibiotics because of fever > 38.5 °C plus CRP > ULN [upper limit of normal]); GvHD (overall grades according to guidelines from Mount Sinai Acute GvHD International Consortium; CMV reactivation (detectable copies of CMV DNA in the peripheral blood plus CMV-active antiviral treatment)
  2. b neutropenic fever on day of transplantation due to antithymocyte globulin (ATG)