Fig. 3

MicroRNA profiling demonstrated distinct miRNA expression profiles in EVs and corresponding whole plasma samples. a Venn diagrams show the differential expression of miRNAs in EV and plasma samples (n = 5). b The heat map shows the unsupervised hierarchical clustering of miRNAs in EVs and plasma samples based on the top 25 miRNAs with highest standard deviation. Red squares mark the representative miRNAs which were differently expressed in EVs and plasma