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Table 2 Overview of precision and reproducibility

From: Plasma contact factors as novel biomarkers for diagnosing Alzheimer’s disease

Biomarker

Sample

U/ml

Intra-assay variation (n = 6)

Inter-assay variation (n = 4)

Mean

SD

CV (%)

Mean

SD

CV (%)

FXIIa

Sample 1

0.5

0.441

0.020

4.5

0.482

0.061

12.7

Sample 2

1.5

1.458

0.047

3.2

1.521

0.165

10.9

Sample 3

2.5

2.469

0.091

3.7

2.668

0.193

7.2

FXIa

Sample 1

0.05

0.058

0.002

2.6

0.053

0.006

11.7

Sample 2

0.1

0.095

0.004

4.2

0.100

0.010

10.1

Sample 3

0.2

0.199

0.008

4.1

0.197

0.019

9.4

FXa

Sample 1

0.1

0.103

0.010

9.4

0.103

0.010

10.2

Sample 2

0.2

0.200

0.011

5.5

0.196

0.017

8.9

Sample 3

0.5

0.510

0.023

4.5

0.515

0.059

11.5

Plasma kallikrein

Sample 1

0.1

0.125

0.004

3.0

0.110

0.012

11.3

Sample 2

0.2

0.191

0.013

6.9

0.190

0.017

8.8

Sample 3

0.4

0.418

0.037

8.8

0.421

0.049

11.8

  1. Both intra (n=6 replicates) and inter-assay (n=4 assays on different day) precision were determined by comparing the mean of triplicates of three deferent concentrations of samples. The % CV is the standard deviation divided by the mean and multiplied by 100. Abbreviations: SD standard deviation, CV coefficients of variation, FXIIa active coagulation factor XII, FXIa active coagulation factor XI, FXa active coagulation factor X