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Table 2 Overview of precision and reproducibility

From: Plasma contact factors as novel biomarkers for diagnosing Alzheimer’s disease

Biomarker Sample U/ml Intra-assay variation (n = 6) Inter-assay variation (n = 4)
Mean SD CV (%) Mean SD CV (%)
FXIIa Sample 1 0.5 0.441 0.020 4.5 0.482 0.061 12.7
Sample 2 1.5 1.458 0.047 3.2 1.521 0.165 10.9
Sample 3 2.5 2.469 0.091 3.7 2.668 0.193 7.2
FXIa Sample 1 0.05 0.058 0.002 2.6 0.053 0.006 11.7
Sample 2 0.1 0.095 0.004 4.2 0.100 0.010 10.1
Sample 3 0.2 0.199 0.008 4.1 0.197 0.019 9.4
FXa Sample 1 0.1 0.103 0.010 9.4 0.103 0.010 10.2
Sample 2 0.2 0.200 0.011 5.5 0.196 0.017 8.9
Sample 3 0.5 0.510 0.023 4.5 0.515 0.059 11.5
Plasma kallikrein Sample 1 0.1 0.125 0.004 3.0 0.110 0.012 11.3
Sample 2 0.2 0.191 0.013 6.9 0.190 0.017 8.8
Sample 3 0.4 0.418 0.037 8.8 0.421 0.049 11.8
  1. Both intra (n=6 replicates) and inter-assay (n=4 assays on different day) precision were determined by comparing the mean of triplicates of three deferent concentrations of samples. The % CV is the standard deviation divided by the mean and multiplied by 100. Abbreviations: SD standard deviation, CV coefficients of variation, FXIIa active coagulation factor XII, FXIa active coagulation factor XI, FXa active coagulation factor X