Table 2 Downstream lncRNAs of TGF-β signaling in HCC
From: Modulation of the TGF-β signaling pathway by long noncoding RNA in hepatocellular carcinoma
LncRNAs | Regulation by TGF-β | Downstream molecules | Function in HCC |
|---|---|---|---|
LncATB | Upregulation | miR-200/ZEB1, ZEB2 | EMT |
YAP, ATG5 | Autophagy | ||
HOTAIR | Upregulation | miR-145/P-gp, BCRP | Multidrug resistance |
HCCL5 | Upregulation | N-cadherin, E-cadherin | EMT |
UCA1 | Upregulation | HXK2 | Tumor Growth |
Linc-ROR | Upregulation | Caspase 8, GADD45B | Chemoresistance |
PVT1 | Upregulation | NOP2 | Tumor Growth |
H19 | Downregulation | TP53/CDKI1A | Progenitor Capacity |