Skip to main content

Table 2 Downstream lncRNAs of TGF-β signaling in HCC

From: Modulation of the TGF-β signaling pathway by long noncoding RNA in hepatocellular carcinoma

LncRNAs Regulation by TGF-β Downstream molecules Function in HCC
LncATB Upregulation miR-200/ZEB1, ZEB2 EMT
   YAP, ATG5 Autophagy
HOTAIR Upregulation miR-145/P-gp, BCRP Multidrug resistance
HCCL5 Upregulation N-cadherin, E-cadherin EMT
UCA1 Upregulation HXK2 Tumor Growth
Linc-ROR Upregulation Caspase 8, GADD45B Chemoresistance
PVT1 Upregulation NOP2 Tumor Growth
H19 Downregulation TP53/CDKI1A Progenitor Capacity
  1. TGF-β transforming growth factor-β; ATG5 Autophagy Related 5; HOTAIR HOX transcript antisense RNA; UCA1 urothelial carcinoma antigen 1; HXK2 Hexokinase-2; GADD45B Growth arrest and DNA damage-inducible protein GADD45 beta; PVT1 plasmacytoma variant translocation 1; NOP2 Nucleolar Protein 2