Table 1 LncRNAs and their mechanisms in HCC suppression and promotion
From: Modulation of the TGF-β signaling pathway by long noncoding RNA in hepatocellular carcinoma
LncRNAs | Effect | Mechanism | Downstream Pathway |
|---|---|---|---|
BZRAP1-AS1 | Oncogene | Epigenetic modification | DNMT3b/THBS1 |
PVT1 | Oncogene | Epigenetic modification | EZH2/MYC |
Linc-GALH | Oncogene | Epigenetic modification | DNMT1/Gankyrin |
DLX6-AS1 | Tumor suppressor | Epigenetic modification | CADM1/Stat3 |
Linc00467 | Oncogene | CeRNA | miR-509-3p/PDGFRA |
Linc00346 | Oncogene | CeRNA | miR-199a-3p/CDK1,CCNB1 |
HULC | Oncogene | CeRNA | miR-675/PKM2 |
CeRNA | miR-2052/MET | ||
RP11-422 N16.3 | Tumor suppressor | CeRNA | miR-23b-3p/DMGDH |
MALAT1 | Oncogene | CeRNA | miR-140/VEGFA |
Alterative Splicing | SRSF1/S6K1 | ||
HAND2-AS1 | Oncogene | Binding to proteins | INO80/BMPR1A |
Linc00324 | Oncogene | Binding to proteins | PU.1/FASL |
Linc01093 | Tumor suppressor | Binding to proteins | IGF2BP1/GLI1 |
SLC2A1-AS1 | Tumor suppressor | Binding to proteins | STAT3/FOXM1/GLUT1 |
PCNA1-AS1 | Oncogene | Antisense | PCNA1 |
LncHOXA10 | Oncogene | Antisense | HOXA10 |