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Table 1 LncRNAs and their mechanisms in HCC suppression and promotion

From: Modulation of the TGF-β signaling pathway by long noncoding RNA in hepatocellular carcinoma

LncRNAs Effect Mechanism Downstream Pathway
BZRAP1-AS1 Oncogene Epigenetic modification DNMT3b/THBS1
PVT1 Oncogene Epigenetic modification EZH2/MYC
Linc-GALH Oncogene Epigenetic modification DNMT1/Gankyrin
DLX6-AS1 Tumor suppressor Epigenetic modification CADM1/Stat3
Linc00467 Oncogene CeRNA miR-509-3p/PDGFRA
Linc00346 Oncogene CeRNA miR-199a-3p/CDK1,CCNB1
HULC Oncogene CeRNA miR-675/PKM2
   CeRNA miR-2052/MET
RP11-422 N16.3 Tumor suppressor CeRNA miR-23b-3p/DMGDH
MALAT1 Oncogene CeRNA miR-140/VEGFA
   Alterative Splicing SRSF1/S6K1
HAND2-AS1 Oncogene Binding to proteins INO80/BMPR1A
Linc00324 Oncogene Binding to proteins PU.1/FASL
Linc01093 Tumor suppressor Binding to proteins IGF2BP1/GLI1
SLC2A1-AS1 Tumor suppressor Binding to proteins STAT3/FOXM1/GLUT1
PCNA1-AS1 Oncogene Antisense PCNA1
LncHOXA10 Oncogene Antisense HOXA10
  1. BZRAP1-AS1 benzodiazapine receptor associated protein 1 antisense RNA 1; DNMT3b DNA methyltransferase 3B; THBS1 thrombospondin-1; PVT1 plasmacytoma variant translocation 1; HULC highly upregulated in liver cancer; Malat1, metastasis-associated lung adenocarcinoma transcript 1; HAND2 heart and neural crest derivatives-expressed transcript 2; DMGDH Dimethylglycine dehydrogenase; GLUT1 Glucose transporter type 1; FOXM1 Forkhead box protein M1