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Table 1 Affinity of Three Types of anti-PD-1 Antibodies [5]

From: Recent updates on Sintilimab in solid tumor immunotherapy

 

Sintilimab

Keytruda

Opdivo

AUC inf (h· μg/mL)

7846.554

8048.861

9349.858

t 1/2 (h)

35.623

42.453

43.505

Cmax (ug/mL)

218.519

224.217

238.710

Vss (mL)

1.262

1.527

1.299

CL (mL/h)

0.025

0.025

0.021

Mean PD-1 receptor occupancy

>95%

NR

>70%

Kd (1/s)

8.028E-5

4.090E+ 6

1.465E-3

Ka (1/Ms)

1.090E+ 6

4.090E+ 6

4.599E+ 5

  1. t1/2 half-life, NR not reported, Kd dissociation constant, Vss volume of distribution at steady state, C max maximum observed concentration, CL clearance, AUC inf area under the serum concentration − time curve extrapolated to infinity (AUC all + C last /λ z), Ka association constant