Assessment of serum macrophage migration inhibitory factor (MIF), adiponectin, and other adipokines as potential markers of proteinuria and renal dysfunction in lupus nephritis: a cross-sectional study

Table 3 Correlations between cytokines and adipokines with clinical variables: including disease activity index, rSLEDAI score, individual markers of renal activity or renal dysfunction and glucocorticoids doses in SLE-patients

	MIF (ng/mL) n = 196		Leptin (ng/mL) n = 196		Adiponectin (μg/mL) n = 196		Resistin (ng/mL) n = 188
	r_s	p	r_s	p	r_s	p	r_s	p
Age, years	−0.21	0.003	0.04	0.62	−0.13	0.07	0.03	0.67
BMI, kg/m²	− 0.06	0.36	0.47	< 0.001	−0.27	< 0.001	0.21	0.004
Disease duration, years	−0.21	0.004	0.06	0.38	−0.07	0.35	0.06	0.42
SLEDAI, score	0.04	0.54	0.09	0.22	0.11	0.13	0.03	0.70
rSLEDAI, score	−0.003	0.96	0.1	0.17	0.21	0.004	0.13	0.07
MEX-SLEDAI, score	0.02	0.75	0.1	0.13	0.16	0.03	0.04	0.58
SLICC/ACR, score	0.15	0.15	0.09	0.24	0.03	0.65	0.19	0.01
Proteinuria, g/24 h	−0.02	0.77	0.18	0.01	0.19	0.009	0.26	< 0.001
Creatinine, mg	0.27	0.04	0.12	0.1	0.16	0.22	0.18	0.02
eGFR (mL/min/m2)	0.11	0.13	0.17	0.02	−0.15	0.05	0.01	0.91
Creatinine clearance (mL/min)	0.07	0.39	0.1	0.89	−0.01	0.18	−0.06	0.44
GCs dose, mg/day	−0.04	0.63	0.1	0.15	0.17	0.02	0.16	0.03

r_s Spearman Rank Correlation, BMI Body mass index, GCs Glucocorticoids, SLE Systemic Lupus Erythematosus, SLEDAI SLE Disease Activity Index, rSLEDAI Renal SLEDAI, MEX-SLEDAI Mexican version of SLEDAI, SLICC/ACR Systemic Lupus International Collaborating Clinics/American College of Rheumatology, eGFR Estimated glomerular filtration rate. Glucocorticoids included: prednisone or deflazacort. GCs dose were expressed as equivalent to prednisone. Spearman Rank Correlation test p < 0.05

ISSN: 2050-7771