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Table 2 Comparison of clinical variables between SLE patients without proteinuria and SLE patients with proteinuria

From: Assessment of serum macrophage migration inhibitory factor (MIF), adiponectin, and other adipokines as potential markers of proteinuria and renal dysfunction in lupus nephritis: a cross-sectional study

Variables Non-Renal-SLE
n = 153
Renal-SLE
n = 43
p
Age (years) a 46 (18–73) 43 (18–62) 0.13
Disease duration, (years) a 9 (2–28) 6 (2–28) 0.10
C3 fraction complement (mg/dL) a 142.0 (60.0–142.0) 154.5 (42.0–252.0) 0.84
C4 fraction complement (mg/dL) a 31 (7.4–71.7) 31.3 (6.7–62.9) 0.92
Positive anti-dsDNA b 39 (25.5) 16 (37.2) 0.27
SLEDAI (score) a 2 (0–12) 6 (4–12) < 0.001
Creatinine clearance (mL/min) a 123.1 (96.6–158.3) 114.9 (80.8–147.0) 0.06
eGFR (mL/min/m2) a 111.2 (29.6–258.9) 108.6 (17.1–182.9) 0.91
Serum creatinine (mg) a 0.7 (0.6–2.2) 0.7 (0.4–3.7) 0.44
Immunosuppressive drugs b 112 (73.2) 33 (76.7) 0.64
Glucocorticoid user b 153 (100) 43 (100)
Glucocorticoid dose (mg/day) a 7.5 (2.5–50.0) 20 (2.5–75.0) < 0.001
Immunosuppressive drugs b 112 (73.2) 33 (76.7) 0.69
 - Azathioprine users b 73 (47.7) 18 (41.8) 0.88
 - Cyclophosphamide users b 9 (5.9) 3 (9.3) 0.29
 - Mycophenolate users b 37 (24.2) 19 (44.2) 0.002
Others drugs (Methotrexate) b 23 (15.0) 4 (9.3) 0.44
  1. a Data expressed as median and range (minimum and maximum value). b Data provided in percentages (n/total patients evaluated). SLE Systemic Lupus Erythematosus, SLEDAI SLE Disease Activity Index, rSLEDAI Renal SLEDAI, MEX-SLEDAI Mexican version of SLEDAI. Estimated glomerular filtration rate (eGFR). Renal-SLE includes patients with proteinuria greater than 0.5 g in 24 h, as sole criterion or in conjunction with persistent hematuria, leucocytes on urine or urine casts by granulocytes or erythrocytes. Glucocorticoids included: prednisone or deflazacort. GCs dose were expressed as equivalent to prednisone. Comparisons between proportions were compared with Chi- square or Fisher exact test (when required). Comparisons between quantitative variables: Mann-Whitney U test