Cohort I | Cohort II | |||||
---|---|---|---|---|---|---|
Univariable | Multivariable | Univariable | Multivariable | |||
n (events) | HR(95% CI) | HR(95% CI) | n (events) | HR(95% CI) | HR(95% CI) | |
Age | ||||||
Continuous | 100 (45) | 1.06 (1.03–1.09) | 1.06 (1.02–1.09) | 260 (82) | 1.05 (1.02–1.08) | 1.04 (1.01–1.08) |
Gender | ||||||
Male | 74 (33) | 1.00 | – | 180 (59) | 1.00 | – |
Female | 26 (12) | 1.15 (0.60–2.24) | – | 80 (23) | 0.88 (0.54–1.42) | – |
Stage | ||||||
pTa | 45 (7) | 1.00 | 1.00 | 114 (16) | 1.00 | 1.00 |
pT1 | 21 (14) | 5.42 (2.18–13.47) | 2.10 (0.69–6.37) | 81 (24) | 2.58 (1.37–4.87) | 1.65 (0.80–3.57) |
≥ pT2 | 34 (24) | 7.98 (3.42–18.60) | 3.39 (1.06–10.91) | 65 (42) | 8.14 (4.55–14.55) | 3.47 (1.45–8.30) |
Grade | ||||||
Low | 47 (8) | 1.00 | 1.00 | 126 (18) | 1.00 | 1.00 |
High | 53 (37) | 6.35 (2.95–13.71) | 2.26 (0.76–6.68) | 134 (64) | 4.47 (2.64–7.54) | 1.44 (0.65–3.20) |
Histology | ||||||
Classic | 209 (48) | 1.00 | 1.00 | |||
Squamous | 14 (10) | 6.12 (3.08–12.15) | 2.39 (1.11–5.14) | |||
Other variant | 37 (24) | 4.44 (2.71–7.27) | 2.04 (1.16–3.59) | |||
LY6D expression | ||||||
Negative (0) | 37 (24) | 1.00 | 1.00 | 93 (38) | 1.00 | 1.00 |
Positive (1–2) | 63 (21) | 0.50 (0.25–0.81) | 0.86 (0.47–1.60) | 167 (44) | 0.58 (0.37–0.89) | 0.78 (0.48–1.25) |