Table 3 Known genes effects on ferroptosis in various cancers
From: Novel insights on targeting ferroptosis in cancer therapy
Tumor type | Gene | Effect | References | Mechanism |
|---|---|---|---|---|
Lymphoma | GPX4 | Inhibition | Yang, W.S et al. [35] | Reduce the accumulation of ROS |
| Â | CHAC1 | Promotion | Wang et al. [65] | Degrade GSH |
HCC | NRF2 | Inhibition | Sun, X et al. [67] | Encode antioxidant proteins |
| Â | HIC1 | Promotion | Xiao Zhang et al. [68] | Affect the synthesis of GSH |
| Â | HNF4A | Inhibition | Â | Â |
| Â | CISD1 | Inhibition | Yuan, H et al. [69] | Suppress mitochondrial lipid peroxidation |
| Â | GABPB1-AS1 | Promotion | Qi, W et al. [70] | Inhibited the cellular antioxidant capacity |
RCC | GPX4 | Inhibition | Yang et al. [35] | Reduce the accumulation of ROS |
| Â | TAZ/NOX | Promotion | Yang et al. [71] | Exhaust intracellular NADPH |
| Â | BAP1 | Inhibition | Zhang, Y et al. [14] | Decreases SLC7A11 expression |
Ovarian cancer | TFR1 | Promotion | Pizzamiglio et al. [72] | Increase the intake of iron |
| Â | TAZ/NOX | Inhibition | Yang et al. [73] | Reduce the depletion of NADPH |
Pancreatic cancer | HSPA5 | Inhibition | Zhu, S et al. [74] | Inhibit the expression of TFR1 |
|  | SystemXc− | Inhibition | Lo M et al. [75] | Increase the synthesis of GSH |
| Â | GRP78 | Inhibition | Wang, K et al. [76] | Unkown |
Breast cancer | TFR1 | Promotion | Basuli et al. [77] | Increase the intake of iron |
| Â | CHAC1 | Promotion | Chen et al. [78] | Degrade GSH |
| Â | ACSL4 | Promotion | Doll, S et al. [79] | Increasing cellular lipid composition |
| Â | P53RRA | Promotion | Chao Mao et al. [80] | Nuclear sequestration of p53 |
Head and neck cancer | NRF2 | Inhibition | Sun, X et al. [81] | Encode antioxidant proteins |
Colorectal cancer | P53 | Inhibition | Xie Y et al. [82] | Increase the expression of systemXc− |
Cervical carcinoma Melanoma | HSPB1 SLC1A5 GOT1 | Inhibition Promotion Inhibition | Stuart et al. [62] Sun, X et al. [29] Luo, M et al. [83] Zhang, K et al. [84] | Inhibit the expression of TFR1 Reduce the accumulation of Glu Decrease the depletion of Glu |