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Table 3 Known genes effects on ferroptosis in various cancers

From: Novel insights on targeting ferroptosis in cancer therapy

Tumor type Gene Effect References Mechanism
Lymphoma GPX4 Inhibition Yang, W.S et al. [35] Reduce the accumulation of ROS
  CHAC1 Promotion Wang et al. [65] Degrade GSH
HCC NRF2 Inhibition Sun, X et al. [67] Encode antioxidant proteins
  HIC1 Promotion Xiao Zhang et al. [68] Affect the synthesis of GSH
  HNF4A Inhibition   
  CISD1 Inhibition Yuan, H et al. [69] Suppress mitochondrial lipid peroxidation
  GABPB1-AS1 Promotion Qi, W et al. [70] Inhibited the cellular antioxidant capacity
RCC GPX4 Inhibition Yang et al. [35] Reduce the accumulation of ROS
  TAZ/NOX Promotion Yang et al. [71] Exhaust intracellular NADPH
  BAP1 Inhibition Zhang, Y et al. [14] Decreases SLC7A11 expression
Ovarian cancer TFR1 Promotion Pizzamiglio et al. [72] Increase the intake of iron
  TAZ/NOX Inhibition Yang et al. [73] Reduce the depletion of NADPH
Pancreatic cancer HSPA5 Inhibition Zhu, S et al. [74] Inhibit the expression of TFR1
  SystemXc Inhibition Lo M et al. [75] Increase the synthesis of GSH
  GRP78 Inhibition Wang, K et al. [76] Unkown
Breast cancer TFR1 Promotion Basuli et al. [77] Increase the intake of iron
  CHAC1 Promotion Chen et al. [78] Degrade GSH
  ACSL4 Promotion Doll, S et al. [79] Increasing cellular lipid composition
  P53RRA Promotion Chao Mao et al. [80] Nuclear sequestration of p53
Head and neck cancer NRF2 Inhibition Sun, X et al. [81] Encode antioxidant proteins
Colorectal cancer P53 Inhibition Xie Y et al. [82] Increase the expression of systemXc
Cervical carcinoma
Melanoma
HSPB1
SLC1A5
GOT1
Inhibition
Promotion
Inhibition
Stuart et al. [62] Sun, X et al. [29]
Luo, M et al. [83]
Zhang, K et al. [84]
Inhibit the expression of TFR1
Reduce the accumulation of Glu
Decrease the depletion of Glu