Fig. 2

Interferon-γ interplay with immune cells. Interferon-γ interacts with IFN-γ-producing cells, such as T-cells, macrophages and dendritic cells in an inflamed or tumor microenvironment. Macrophages: IFN-γ stimulates polarization of macrophages toward M1 proinflammatory phenotype and enhances their capacity for chemokines secretion. Dendritic cells: Maturation, MHC I and II up-regulation through increased IRF1 expression, and decreased survival of dendritic cells is IFN-γ dependent. T-cells: IFN-γ interacts with T-cells to stimulate their differentiation toward the Th1 subset. Through a positive feedback loop IFN-γ stimulates its own production in Th1 cells and inhibits Th2 and Th17 differentiation. IFN-γ is required for maturation of naïve T-cells to effector CD8+ T-cells. The IFN-γ is main cytotoxic molecule secreted by these cells. Immune-suppressive T regulatory cells are inhibited by IFN-γ