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Fig. 2 | Biomarker Research

Fig. 2

From: Epigenetic based synthetic lethal strategies in human cancers

Fig. 2

Synthetic lethality based on epigenetic defects. A. Synthetic lethality induced by combined BER inhibitor and epigenetic inactivation of MMR (inhibition of POLB selectively impair MSH2-deficient endometrial cancer cells). B. Synthetic lethality induced by combined DSB repair inhibitor and epigenetic inactivation of SSB repair (inhibition of ATM or DNA-PKcs selectively impair XRCC1-deficient breast cancer cells). C. Synthetic lethality induced by combined MMEJ repair inhibitor and epigenetic inactivation of HR repair (inhibition of POLQ selectively impair HR-deficient ovarian cancer cells). BER, base excision repair; MMR, mismatch repair; POLB, polymerase theta; SSBs, single-strand breaks; DSBs, double-strand breaks; HR, homologous recombination repair; MMEJ, microhomology mediated end joining; POLQ, polymerase theta

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