Skip to main content
Fig. 2 | Biomarker Research

Fig. 2

From: The role of estrogen receptor beta in breast cancer

Fig. 2

ERβ reduces VEGF transcription via reducing HIF-1α/ARNT complexes. ERβ attenuated the hypoxic induction of VEGF mRNA by directly reducing HIF-1α/ARNT complexes binding to VEGF gene promoter. The inhibition of HIF-1α activity is related to the ability of ERβ to degrade ARNT via ubiquitination processes, leading to the reduction of active HIF-1α/ARNT complexes

Back to article page