Fig. 5
From: The biological function and clinical significance of SF3B1 mutations in cancer
Molecular effects of SF3B small-molecule inhibitors on 3ʹ splice site recognition mediated by SF3B1 mutation. a: Normal condition of 3ʹ splice site recognition induced by SF3B1WT. b: Effects of inhibitors on 3ʹ splice site recognition induced by SF3B1WT. PlaB inhibits mRNA splicing by fitting into a space between SF3B1 and SF3B3; E7101 and SSA inhibit splicing by fitting into SF3B1. c: Effects of inhibitors on 3ʹ splice site recognition induced by SF3B1MUT. Mutations impair the binding of PlaB, E7101 or SSA to SF3B1