Fig. 3
From: The biological function and clinical significance of SF3B1 mutations in cancer
A model for aberrant 3′ ss selection induced by SF3B1 mutations. a: Schematic representation of SF3B1WT-mediated splicing, generating canonical transcript and producing canonical protein. b: Schematic representation of SF3B1MUT-mediated splicing, leading to the binding of U2 snRNP and alternative branchpoint sequence (BPSʹ) or usage of a cryptic 3′ splice and resulting in aberrant/alternative transcript with aberrant/alternative protein as well as increased nonsense-mediated decay (MMD)