Table 2 Summary results of the meta-analysis of mean values of each Biomarker in severe vs non-severe cases

0.72 (0.34;1,11)

< 0.001

87

6

467

1042

1.34 (0.83;1.86)

< 0.001

95

9

670

1304

0.93 (0.25;1.61)

0.007

93

3

369

506

0.27 (−0.16;0.70)

0.22

90

4

435

1029

-0.57 (−0.71; −0.42)

< 0.001

61

12

888

2449

-0.81 (−1.12; − 0.49)

< 0.001

62

3

367

306

-0.26 (− 0.48; − 0.04)

0.02

72

7

445

1619

−0.28 (− 0.50; − 0.06)

0.01

0

2

114

322

0.52 (0.28;0.76)

< 0.001

80

9

646

1510

−0.20 (− 0.37; − 0.03)

0.02

0

4

165

678

−0.09(− 0.27;0.08)

0.30

14

4

372

426

0.13 (−0.14;0.39)

0.35

90

11

1133

2566

−0.77(−0.95; − 0.59)

< 0.001

0

2

307

437

0.68(0.48;0.87)

< 0.001

30

4

185

965

0.71(0.42;1.00)

< 0.001

0

2

57

373

0.48(0.10;0.87)

0.01

89

7

343

1317

1.14(0.81;1.47)

< 0.001

66

3

149

863

0.53(0.34;0,71)

< 0.001

68

10

507

1785

0.96(0.58;1.34)

< 0.001

91

9

453

1650

−1.67(−2.40; −0.94)

< 0.001

93

4

185

855

0.18(0.01;0.35)

0.04

49

8

368

1417

0.58(0.23;0.93)

0.001

83

5

277

920

0.32(0.18;0.47)

< 0.001

28

7

344

1253

1.36(0.75;1.98)

< 0.001

95

7

343

1317

−0.10(−0.43;0.23)

0.55

79

3

248

1061

−0.19(− 0.72;0.34)

0.49

91

3

231

983

1.03(0.83;1.22)

< 0.001

0

2

143

473

0.48(0.23;0.73)

< 0.001

16

3

111

246

0.54(0.31;0.77)

< 0.001

69

7

348

1235

0.17(−0.23;0.57)

0.40

74

4

164

274

0.09(−0.56;0.74)

0.78

77

2

56

320