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Table 2 Summary results of the meta-analysis of mean values of each Biomarker in severe vs non-severe cases

From: A meta-analysis of potential biomarkers associated with severity of coronavirus disease 2019 (COVID-19)

Anomalies SMD (95% CI) P-value Heterogeneity
I2 (%)
Number of studies Sample size for severe Sample size for Non-severe
Inflammation
 Procalcitonin 0.72 (0.34;1,11) < 0.001 87 6 467 1042
 CRP 1.34 (0.83;1.86) < 0.001 95 9 670 1304
 IL-6 0.93 (0.25;1.61) 0.007 93 3 369 506
 ESR 0.27 (−0.16;0.70) 0.22 90 4 435 1029
Blood routine
 Lymphocytes count -0.57 (−0.71; −0.42) < 0.001 61 12 888 2449
 Lymphocytes % -0.81 (−1.12; − 0.49) < 0.001 62 3 367 306
 Thrombocytes -0.26 (− 0.48; − 0.04) 0.02 72 7 445 1619
 Eosinophils −0.28 (− 0.50; − 0.06) 0.01 0 2 114 322
 Neutrophils 0.52 (0.28;0.76) < 0.001 80 9 646 1510
 Haemoglobin −0.20 (− 0.37; − 0.03) 0.02 0 4 165 678
 Monocytes −0.09(− 0.27;0.08) 0.30 14 4 372 426
 White Blood Cells 0.13 (−0.14;0.39) 0.35 90 11 1133 2566
 CD3+ T −0.77(−0.95; − 0.59) < 0.001 0 2 307 437
Cardiac injury biomarkers
 CK-MB 0.68(0.48;0.87) < 0.001 30 4 185 965
 Troponin I 0.71(0.42;1.00) < 0.001 0 2 57 373
Biochemestry
 CK 0.48(0.10;0.87) 0.01 89 7 343 1317
 Myoglobin 1.14(0.81;1.47) < 0.001 66 3 149 863
 ALAT 0.53(0.34;0,71) < 0.001 68 10 507 1785
 ASAT 0.96(0.58;1.34) < 0.001 91 9 453 1650
 Albumin −1.67(−2.40; −0.94) < 0.001 93 4 185 855
 Creatinemia 0.18(0.01;0.35) 0.04 49 8 368 1417
 Blood urea nitrogen 0.58(0.23;0.93) 0.001 83 5 277 920
 Total bilirubin 0.32(0.18;0.47) < 0.001 28 7 344 1253
 LDH 1.36(0.75;1.98) < 0.001 95 7 343 1317
 Potassium −0.10(−0.43;0.23) 0.55 79 3 248 1061
 Sodium −0.19(− 0.72;0.34) 0.49 91 3 231 983
 γ-GT 1.03(0.83;1.22) < 0.001 0 2 143 473
Blood clothing
 PT 0.48(0.23;0.73) < 0.001 16 3 111 246
 D-dimer 0.54(0.31;0.77) < 0.001 69 7 348 1235
 aPT 0.17(−0.23;0.57) 0.40 74 4 164 274
 Fibrinogen 0.09(−0.56;0.74) 0.78 77 2 56 320
  1. SMD Standardized mean difference; CRP C-reactive protein; CK Creatine kinase; IL-6 interleukin-6; ALAT alanine amino-transferase;
  2. ASAT aspartate amino-transferase; LDH Lactate dehydrogenese; PT prothrombin time; aPT activated partial thromboplastin;