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Table 1 Characteristics of included studies

From: A meta-analysis of potential biomarkers associated with severity of coronavirus disease 2019 (COVID-19)

Cai Qi Case serie China Shenzhen Single center Hospital Retrospective Non-servere Vs Servere 417 85 NR 233 NR NR NR
Cai Q Case serie China Shenzhen Single center Referal hospital Retrospective Non-servere Vs Servere 298 58 62.5 240 41 Liver diseases:13.9%; Type II diabetes:13.8%; Hypertension:37.9%;
Cardiac diseases:22.4%;
Liver diseases:8.3%; Type II diabetes:4.2; Hypertension:10.4;
Cardiac diseases:5.0%
Chen X Case serie China Chongqing Single center Hospital Retrospective Non-servere Vs Servere 78 15 NR 63 NR NR NR
Chen G Case serie China Wuhan Single center Hospital Retrospective Moderate Vs Severe 21 11 61 10 52 Hypertension: 36.4%; diabetes: 18.2% Hypertension: 10%; diabetes:10%
Fan B Case serie Singapore Unclear Single center Hospital Prospective ICU VS No-ICU 67 9 54 58 41 NR NR
Feng Y Case serie China Wuhan Multicenter Hospital Retrospective Moderate Vs Critical 476 70 61 352 51 Hypertension: 35.7%; diabetes 8.6%; cardiovascular diseases: 17.1%; malignancy: 8.6%;COPD: 15.7%;immunosuppression: 7.1%; Hypertension: 20.7%;diabetes 9.1%; cardiovascular diseases 6%; malignancy: 1.4%;COPD: 2.3%;immunosuppression: 0.6%;
Guan W Case serie China Unclear Multicenter Unclear Retrospective Admission to an intensive care unit (ICU), use of mechanical ventilation, or death 1099 173 52 926 45 Hepatitis B: 2.4%; Diabetes:16.2%;Hypertention: 23.7%;COPD:3.5%; CHD: 5.8%; Cerebro-Vas diseases: 2.3%;Immunodeficiency:0%;Cancer: 1.7% Hepatitis B: 0.6%; Diabetes: 5.7%;Hypertention:13.4%;COPD: 0.6%; CHD: 1.8%; Cerebro-Vas diseases:1.2%;Immunodeficiency:0.2%;Cancer:0.8%
Han H Cross sectional China Wuhan Single center Hospital Prospective Ordinary Vs Severe 94 35 NR 49 NR NR NR
Huang C Case serie China Wuhan Single center Hospital Prospective Non-servere Vs Servere 41 13 49 28 49 Diabetes:8%;Hypertention: 15%;COPD:8%; CVD: 23%;Immunodeficiency:%;Cancer: 0% Diabetes: 25%;Hypertention: 14%;COPD:0%;CVD: 11%;Cancer: 4%
Li Y Case serie China Huazhong Single center Department of Thoracic Surgery Retrospective Non-servere Vs Servere 25 9 NR 16 NR Hypertention: 11.1%;COPD:44.4%;diabetes:11.1%;CHD: 11.1 Hypertention:6.3%;COPD:6.3%;diabetes: 0%;CHD:18.8
Li K Case serie China Unclear Single center Hospital Retrospective Non-servere Vs Servere 83 25 53.7 58 41 Hypertention:8%;COPD: 16.0%;diabetes:28.0%;CHD: 4.0% Hypertention5.2%;COPD: 1.7%;diabetes:0.0%;CHD:0.0%
Liu Y Case serie China Shenzhen Single center Hospital Retrospective Mechanical ventilation VS No Mechanical ventilation 12 6 64.5 6 52 Hypertention:17.6%;COPD:%;diabetes:16.7%;CHD:33.3%;cancer:0%;chronic liver diseases:0%; chronic renal diseases:16.7%
Liu W Case serie China Wuhan Multicenter Hospital Retrospective Common Vs Severe 78 8 NR 70 NR Hypertention:10.3%;COPD: 5.1%;diabetes:6.4%;cancer:5.1%
Mao L Case serie China Wuhan Multicenter Neurology Retrospective Non-servere Vs Servere 214 88 58.2 126 48.9 Hypertention:36.4%; diabetes: 17.0%; cardiac/cerebral disease: 8.0%;
Cancer: 5.7%; chronic kidney disease:2.3%
Hypertention: 15.1%; diabetes:11.9%; cardiac/cerebral disease:6.3%;
Cancer:6.3%; chronic kidney disease:3.2%
Qian G Case serie China Zhejiang Multicenter Hospital Retrospective Non-servere Vs Servere 91 9 66 82 49 NR NR
Qin C Case serie China Tongji Single center Hospital Retrospective Non-servere Vs Servere 452 286 61 166 53 Hypertention:36.7%;COPD: 3.1%;diabetes:18.5%;cancer:3.5%;CVD:8.4;CeVD:2.8%; chronic liver diseases: 1%;Tuberculosis:2.4%; chronic kidney diseases: 2.1% Hypertention:18.1%;COPD: 1.8%;diabetes:13.3%;cancer:2.4%;CVD:1.8%;CeVD:1.8%; chronic liver diseases:1.8%;Tuberculosis:1.2%; chronic kidney diseases: 2.4%
Qiu H Case serie China Zhejiang Multicenter Paediatric Retrospective Mild Vs Moderate 36 19 9 17 7.5 NR NR
Qu R Case serie China Huizhou Single center Hospital Retrospective Non-servere Vs Servere 30 3 60 27 49.4 NR NR
Ruan Q Case serie China Jin,Tongji Multicenter Hospital Retrospective Death Vs Discharge 150 68 NR 82 NR NR NR
Wan S Case serie China Chongqing Single center Hospital Retrospective Non-servere Vs Servere 135 40 56 95 44 Hypertention:10%;COPD:10%;diabetes:22.5%;cancer: 7.5%;CVD:15%;chronic liver diseases:2.5%; pulmonary diseases:2.5% Hypertention:9.4%;COPD:0%;diabetes: 3.1%;cancer:1.5%;CVD:1%; chronic liver diseases: 1%;Tuberculosis: %;diseases:0%
Wang Z Case serie China Wuhan Multicenter Hospital Retrospective Non-servere Vs Servere 69 14 70.5 55 37 Hypertention:36%;COPD: 14%;diabetes:43%;cancer: 7%;CVD:36%;chronic liver diseases:0%; Hypertention: 7%;COPD: 4%;diabetes: 2%;cancer: 5%;CVD:5%;chronic liver diseases:2%
Wang R Case serie China Fuyang Single center Hospital Retrospective Non-servere Vs Servere 125 25 49.4 100 39.7 Comorbidities: 48% Comorbidities:22%
Wang D Case serie China Wuhan Single center Hospital Retrospective Non-servere Vs Servere 138 36 66 102 51 Hypertention:58.3%;COPD: 8.3%;diabetes:22.2%;cancer:11.1%;CVD:25.0%;chronic liver diseases:0%; CeVD:16.7%;HIV:0% Hypertention:21.6%;COPD:1.0%;diabetes:5.9%;cancer: 5.9%;CVD:10.8%;chronic liver diseases:3.9%; CeVD:1.0%;HIV:2.0%
Wu C Case serie China Wuhan Single center Hospital Retrospective Survivor Vs Non-survivor 201 44 68.5 40 50 aHypertention:36.4%; diabetes:25.0%; CVD:9.1% aHypertention:17.5%; diabetes:12.5%;CVD:2.5%
Xu Y Case serie China Unclear Single center Radiology Retrospective Mild/Moderate/Severe/critical 50 3 NR 9 NR NR NR
Yang X Case serie China Wuhan Single center Hospital Retrospective Survivor Vs Non-survivor 52 32 64.6 20 59.7 aCOPD:6%;diabetes:22%;cancer:3%;CVD:9%;chronic liver diseases:0%; CeVD:22% aCOPD:10%;diabetes:10%;cancer:5%;CVD:10%;chronic liver diseases:0%;CeVD:0%
Young B Case serie Singapore NR Multicenter Hospital Retrospective Require Vs not require supp Oxygen 18 6 56 12 37 Comorbidities:67% Comorbidities:8%
Yun L Case serie China Shanghai Single center Hospital Retrospective No-servere Vs Servere 292 21 65.5 271 48.7 NR NR
Zhang J Case serie China Wuhan Multicenter Hospital Retrospective Non-servere Vs Servere 140 58 64 82 51.5 Hypertention:37.9%; COPD:3.4%; diabetes:13.8%;CHD:6.9%;liver diseases:6.9%; CeVD: 3.4% Hypertention:24.4%; COPD:0%; diabetes:11.0%;CHD:3.7%;liver diseases:5.0%; CeVD: 1.2%
Zheng F Case serie China Changsha Single center Hospital Retrospective Non-servere Vs Servere 161 30 57 131 40 Hypertention:40%; COPD:6.7%; diabetes:6.7%; CHD:6.7%;chronic liver diseases:3.1%; CeVD:3.3% Hypertention:7.6%; COPD:3.1%; diabetes:3.8%;CHD:1.5%;chronic liver diseases:0%;CeVD:2.3%
Zhou F Case serie China Wuhan Multicenter Pulmonary hospital Retrospective Survivor Vs Non-survivor 191 54 69 137 52 a Hypertention:48%; COPD:7%; diabetes: 31%; cancer:0%; CHD:14%;chronic kidney diseases:4% a Hypertention: 23%; COPD:1%; diabetes: 14%; cancer:1%; CHD:1%;chronic kidney diseases:1%
  1. aSurvivor Vs Non-survivors; CeVD Cerebrovascular diseases; CVD Cardiovascular diseases; COPD chronic obstructive pulmonary diseases; CHD coronary heart diseases; NR Not reported