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Table 2 Selection for orginal variables associated with the presence of fibrosis stage in the training set

From: FibroBox: a novel noninvasive tool for predicting significant liver fibrosis and cirrhosis in HBV infected patients

Variables

Spearman correlation analysis

Combined multivariate analysis

r value

p value

Significant fibrosis vs none

Cirrhosis vs F0–3

Age (years)

0.223

< 0.001

  

Male sex, n (%)

−0.021

0.630

  

BMI

−0.013

0.770

  

ALT (IU/L)

0.030

0.489

  

AST (IU/L)

0.171

< 0.001

GGT (IU/L)

0.187

< 0.001

Total bilirubin (IU/L)

0.110

0.010

  

Platelet count (109/L)

−0.356

< 0.001

WBC (109/L)

−0.257

< 0.001

  

PT (s)

0.321

< 0.001

ALP (IU/L)

0.094

0.027

  

Albumin (g/L)

−0.144

0.001

  

Cholesterol (mmol/L)

−0.071

0.099

  

INR

0.356

< 0.001

  

PIIINP (ng/ml)

0.330

< 0.001

Type IV collagen (ng/ml)

0.478

< 0.001

Laminin (ng/ml)

0.465

< 0.001

HA (ng/ml)

0.444

< 0.001

Ultrasound size of spleen (mm2)

0.223

< 0.001

  

Ultrasound diameter of spleen vein (mm)

0.097

0.024

  

Ultrasound diameter of portal vein (mm)

0.138

0.001

Ultrasound velocity of portal vein (m/s)

0.179

< 0.001

  

Fibroscan results (kPa)

0.767

< 0.001

  1. ALT alanine transaminase, ALP alkaline phosphatase, AST aspartate transaminase, BMI body mass index, GGT gamma-glutamyl transpeptidase, HA hyaluronic acid, INR international normalized ratio, PIIINP type III procollagen aminoterminal peptide, PT prothrombin time, WBC white blood cell