Skip to main content

Table 2 Selection for orginal variables associated with the presence of fibrosis stage in the training set

From: FibroBox: a novel noninvasive tool for predicting significant liver fibrosis and cirrhosis in HBV infected patients

Variables Spearman correlation analysis Combined multivariate analysis
r value p value Significant fibrosis vs none Cirrhosis vs F0–3
Age (years) 0.223 < 0.001   
Male sex, n (%) −0.021 0.630   
BMI −0.013 0.770   
ALT (IU/L) 0.030 0.489   
AST (IU/L) 0.171 < 0.001
GGT (IU/L) 0.187 < 0.001
Total bilirubin (IU/L) 0.110 0.010   
Platelet count (109/L) −0.356 < 0.001
WBC (109/L) −0.257 < 0.001   
PT (s) 0.321 < 0.001
ALP (IU/L) 0.094 0.027   
Albumin (g/L) −0.144 0.001   
Cholesterol (mmol/L) −0.071 0.099   
INR 0.356 < 0.001   
PIIINP (ng/ml) 0.330 < 0.001
Type IV collagen (ng/ml) 0.478 < 0.001
Laminin (ng/ml) 0.465 < 0.001
HA (ng/ml) 0.444 < 0.001
Ultrasound size of spleen (mm2) 0.223 < 0.001   
Ultrasound diameter of spleen vein (mm) 0.097 0.024   
Ultrasound diameter of portal vein (mm) 0.138 0.001
Ultrasound velocity of portal vein (m/s) 0.179 < 0.001   
Fibroscan results (kPa) 0.767 < 0.001
  1. ALT alanine transaminase, ALP alkaline phosphatase, AST aspartate transaminase, BMI body mass index, GGT gamma-glutamyl transpeptidase, HA hyaluronic acid, INR international normalized ratio, PIIINP type III procollagen aminoterminal peptide, PT prothrombin time, WBC white blood cell