AML risk stratification models utilizing ELN-2017 guidelines and additional prognostic factors: a SWOG report

Biomarker Research

Table 4 Performance of simplified ELN-2017 risk stratification criteria

Covariates	Discovery	Validation
Complete Response (CR, AUC)
ELN₂₀₁₇	0.65	0.74
AGE + ELN₂₀₁₇	0.71	0.76
ELN_2017-MOD	0.65	0.72
AGE + ELN_2017-MOD	0.71	0.77
Overall Survival (OS, C Statistic)
ELN₂₀₁₇	0.60	0.68
AGE + ELN₂₀₁₇	0.71	0.73
ELN_2017-MOD	0.60	0.67
AGE + ELN_2017-MOD	0.72	0.73
Relapse-Free Survival (RFS, C Statistic)
ELN₂₀₁₇	0.64	0.62
AGE + ELN₂₀₁₇	0.68	0.67
ELN_2017-MOD	0.62	0.63
AGE + ELN_2017-MOD	0.67	0.68

Comparison of predictive value of ELN₂₀₁₇ and ELN_2017-MOD and change in predictive value with the addition of age as a covariate

ISSN: 2050-7771