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Table 2 Univariate Analyses in the Discovery Cohort

From: AML risk stratification models utilizing ELN-2017 guidelines and additional prognostic factors: a SWOG report

Variable Complete Response, CR (N = 185) Overall Survival, OS (N = 185) Relapse-Free Survival, RFS (N = 106)
OR (95% CI) P HR (95% CI) P HR (95% CI) P
Age Continuous 0.96 (0.94–0.98) < 0.001 1.06 (1.04–1.07) < 0.001 1.04 (1.02–1.05) < 0.001
By Decade 0.66 (0.53–0.82) < 0.001 1.75 (1.52–2.01) < 0.001 1.41 (1.20–1.67) < 0.001
Cytogenetics Fav. vs. Interm. 5.29 (1.15–24.40) 0.033* 0.24 (0.10–0.59) 0.002* 0.29 (0.12–0.69) 0.005*
Unfav. vs. Interm. 0.42 (0.18–0.97) 0.043* 1.77 (1.12–2.79) 0.014* 1.38 (0.71–2.68) 0.349*
Unk. vs. Interm. 0.57 (0.28–1.16) 0.124* 1.25 (0.84–1.88) 0.271* 0.80 (0.46–1.41) 0.446*
Performance Status Numeric 0.82 (0.58–1.15) 0.246 1.07 (0.89–1.30) 0.462 0.84 (0.62–1.15) 0.278
2–3 vs. 0–1 0.37 (0.17–0.81) 0.013 1.49 (0.97–2.29) 0.07 1.01 (0.50–2.03) 0.971
Study S0106 vs S9031 2.88 (1.20–6.87) 0.018* 0.28 (0.17–0.46) < 0.001* 0.35 (0.18–0.69) 0.002*
S9333 vs S9031 1.04 (0.40–2.73) 0.934* 0.87 (0.53–1.43) 0.58* 0.79 (0.38–1.67) 0.54*
S0112 vs S9031 0.63 (0.17–2.33) 0.484* 1.16 (0.61–2.22) 0.645* 0.79 (0.27–2.30) 0.669*
Immunophenotype 2 vs 0 1.37 (0.68–2.75) 0.384 1.14 (0.77–1.70) 0.504 1.26 (0.76–2.08) 0.373
1 vs 0 0.73 (0.33–1.57) 0.415 1.02 (0.64–1.61) 0.946 0.97 (0.51–1.86) 0.928
AML Onset Secondary vs. DN 0.23 (0.08–0.67) 0.007 1.89 (1.10–3.25) 0.02 0.95 (0.30–3.01) 0.925
ELN2017 in MNCs Fav. vs. Interm. 3.11 (1.16–8.32) 0.024* 0.58 (0.32–1.02) 0.06* 0.47 (0.24–0.92) 0.027*
Adv. vs. Interm. 0.64 (0.27–1.56) 0.328* 1.66 (1.00–2.77) 0.05* 1.72 (0.88–3.35) 0.113*
Unk. vs. Interm. 0.72 (0.29–1.75) 0.467* 1.32 (0.78–2.23) 0.305* 0.76 (0.37–1.54) 0.441*
ELN2017 in VLBs Fav. vs. Interm. 3.69 (1.30–10.52) 0.014* 0.38 (0.21–0.68) 0.001* 0.37 (0.18–0.77) 0.008*
Adv. vs. Interm. 0.77 (0.30–1.98) 0.587* 1.10 (0.66–1.84) 0.72* 1.45 (0.71–2.97) 0.312*
Unk. vs. Interm. 0.96 (0.37–2.47) 0.928* 0.78 (0.46–1.33) 0.36* 0.64 (0.31–1.35) 0.242*
  1. * Indicates that the overall p-value was significant (< 0.05)