Table 2 Univariate Analyses in the Discovery Cohort

0.96 (0.94–0.98)

< 0.001

1.06 (1.04–1.07)

< 0.001

1.04 (1.02–1.05)

< 0.001

0.66 (0.53–0.82)

< 0.001

1.75 (1.52–2.01)

< 0.001

1.41 (1.20–1.67)

< 0.001

5.29 (1.15–24.40)

0.033*

0.24 (0.10–0.59)

0.002*

0.29 (0.12–0.69)

0.005*

0.42 (0.18–0.97)

0.043*

1.77 (1.12–2.79)

0.014*

1.38 (0.71–2.68)

0.349*

0.57 (0.28–1.16)

0.124*

1.25 (0.84–1.88)

0.271*

0.80 (0.46–1.41)

0.446*

0.82 (0.58–1.15)

0.246

1.07 (0.89–1.30)

0.462

0.84 (0.62–1.15)

0.278

0.37 (0.17–0.81)

0.013

1.49 (0.97–2.29)

0.07

1.01 (0.50–2.03)

0.971

2.88 (1.20–6.87)

0.018*

0.28 (0.17–0.46)

< 0.001*

0.35 (0.18–0.69)

0.002*

1.04 (0.40–2.73)

0.934*

0.87 (0.53–1.43)

0.58*

0.79 (0.38–1.67)

0.54*

0.63 (0.17–2.33)

0.484*

1.16 (0.61–2.22)

0.645*

0.79 (0.27–2.30)

0.669*

1.37 (0.68–2.75)

0.384

1.14 (0.77–1.70)

0.504

1.26 (0.76–2.08)

0.373

0.73 (0.33–1.57)

0.415

1.02 (0.64–1.61)

0.946

0.97 (0.51–1.86)

0.928

0.23 (0.08–0.67)

0.007

1.89 (1.10–3.25)

0.02

0.95 (0.30–3.01)

0.925

3.11 (1.16–8.32)

0.024*

0.58 (0.32–1.02)

0.06*

0.47 (0.24–0.92)

0.027*

0.64 (0.27–1.56)

0.328*

1.66 (1.00–2.77)

0.05*

1.72 (0.88–3.35)

0.113*

0.72 (0.29–1.75)

0.467*

1.32 (0.78–2.23)

0.305*

0.76 (0.37–1.54)

0.441*

3.69 (1.30–10.52)

0.014*

0.38 (0.21–0.68)

0.001*

0.37 (0.18–0.77)

0.008*

0.77 (0.30–1.98)

0.587*

1.10 (0.66–1.84)

0.72*

1.45 (0.71–2.97)

0.312*

0.96 (0.37–2.47)

0.928*

0.78 (0.46–1.33)

0.36*

0.64 (0.31–1.35)

0.242*