Fig. 2
From: The emerging roles of N6-methyladenosine RNA methylation in human cancers
The mechanism of METTL3 in LC as on oncogenic role. The up-regulated METTL3 can promote the expression of some oncogenes like EGFR, TAZ, MK2, DNMT3 in am m6A-dependent manner and finally leads to LC, And it can also inhibit VASH1 by stimulating the spicing of precursor miR-143-3p, which is responsible for the brain metasis. As a writer, METTL3 can facilitate the translation of some oncogenes such a BRD4 and ultimately contribute to the LC/