Fig. 2
From: Roles of HMGB1 in regulating myeloid-derived suppressor cells in the tumor microenvironment
HMGB1 regulates MDSCs in the TME. EXO-HMGB1: exosomal HMGB1. In the TME, secreted HMGB1 mediates MDSC activation through NF-κB, thereby promoting the MDSC development from BM progenitor cells, contributing to MDSC-mediated T cell suppression, enhancing the crosstalk between MDSCs and macrophages, and downregulating the expression of the T cell homing receptor L-selectin. In addition, HMGB1 can mediate the survival of MDSC through autophagy while inhibiting the immunosuppressive activity of MDSC. Currently, the regulatory effect of EXO-HMGB1 on unclear is unclear and needs further exploration