Table 3 Characteristics of LOX-low/LOX-high extramedullary AML
all EM AML n = 59 | ||||
|---|---|---|---|---|
all EM AML n = 59 | LOX-low group n = 28, 60% | LOX-high group n = 31, 40% | p-value | |
age at diagnosis median (range) | 46 (17–60) | 45 (17–60) | 49 (22–59) | 0.538 |
Gender, Female, no. (percent) | 24 (41) | 13 (46) | 11 (35) | 0.393 |
Bone marrow blasts at diagnosis [percent] median (range) | 63 (20–96) | 68.5 (20–94) | 62.5 (20.5–96) | 0.792 |
WBC count at diagnosis [Gpt/L] median (range) | 26.9 (1.3–191.4) | 38 (1.4–191.4) | 18.8 (1.3–189.1) | 0.370 |
Platelet count at diagnosis [Gpt/L] median (range) | 52 (13–357) | 61 (13–231) | 50 (13–357) | 0.970 |
Serum LDH at diagnosis [U/l] median (range) | 707 (145–4945) | 694 (186–4945) | 768 (145–3973) | 0.439 |
FLT3-ITD mutational status, positive, no. (percent) | 12 (25) | 8 (29) | 4 (13) | 0.135 |
NPM1 mutational status, NPM1 mut, no. (percent) | 21 (36) | 10 (37) | 11 (35) | 0.902 |
Combined NPM1/FLT3 status, no. (percent) | ||||
NPM1 wt/FLT3 wt | 32 (55) | 14 (52) | 18 (58) | 0.413 |
NPM1 wt/FLT3 mut | 5 (9) | 3 (11) | 2 (6) | |
NPM1 mut/FLT3 wt | 14 (24) | 5 (18) | 9 (29) | |
NPM1 mut/FLT3 mut | 7 (12) | 5 (18) | 2 (6) | |
Disease status at diagnosis, no. (percent) | ||||
De novo AML | 53 (90) | 28 (100) | 25 (81) | 0.049 |
tAML | 5 (8) | 0 (0) | 5 (16) | |
mdsAML | 1 (2) | 0 (0) | 1 (3) | |
FAB subtypes at diagnosis, no. (percent) | ||||
M0 | 2 (3) | 0 (0) | 2 (6) | 0.003 |
M1 | 11 (19) | 9 (32) | 2 (6) | |
M2 | 14 (24) | 10 (36) | 4 (13) | |
M4 | 9 (15) | 2 (7) | 7 (23) | |
M4eo | 2 (3) | 2 (7) | 0 (0) | |
M5a | 11 (19) | 1 (4) | 10 (32) | |
M5b | 2 (3) | 0 (0) | 2 (6) | |
M6 | 2 (3) | 1 (4) | 1 (3) | |
M7 | 1 (2) | 0 (0) | 1 (3) | |
RAEB-T | 3 (5) | 1 (4) | 2 (6) | |
M5 other | 2 (3) | 2 (7) | 0 (0) | |
Cytogenetic subgroups, no. (percent) | ||||
High risk | 19 (32) | 3 (11) | 16 (52) | 0.001 |
Standard risk | 33 (56) | 19 (68) | 14 (45) | |
Low risk | 7 (12) | 6 (21) | 1 (3) | |
Detailed karyotypes, no. (percent) | ||||
Complex karyotype | 12 (20) | 3 (11) | 9 (29) | 0.081 |
Normal karyotype | 18 (32) | 12 (44) | 6 (20) | 0.047 |
t(8;21) | 4 (7) | 3 (11) | 1 (3) | 0.253 |
inv16 | 3 (5) | 3 (11) | 0 (0) | 0.061 |
monosomy 5 | 2 (3) | 0 (0) | 2 (6) | 0.171 |
del5q | 3 (5) | 1 (4) | 2 (6) | 0.615 |
monosomy 7 | 1 (2) | 1 (4) | 0 (0) | 0.289 |
del7q | 3 (5) | 1 (4) | 2 (6) | 0.615 |
monosomy other than chromosomes 5 or 7 | 3 (5) | 1 (4) | 2 (6) | 0.615 |
trisomy 8 | 11 (19) | 3 (11) | 8 (26) | 0.137 |
t(9;11) | 3 (5) | 0 (0) | 3 (10) | 0.091 |
abnl(11q23) | 10 (17) | 1 (4) | 9 (29) | 0.009 |