Table 4 Performance of GAS5, calretinin, mesothelin, linear combination, and sequential combination of the markers
GAS5 | Calretinin | Mesothelin | Calretinin and mesothelin | GAS5, calretinin, and mesothelin | Mesothelin, GAS5, and calretinin | |
|---|---|---|---|---|---|---|
Combination | – | – | – | Sequential | Linear | Sequential |
N | 53 | 53 | 52 | 52 | 52 | 52 |
AUC | 0.86 | 0.84 | 0.75 | 0.88 | 0.88 | 0.96 |
(95% CI 0.75–0.98) | (95% CI 0.74–0.96) | (95% CI 0.61–0.89) | (range 0.76–0.88) | (95% CI 0.78–0.99) | (range 0.85–0.96) | |
Cut-off | 25.496 | 1.044 | 2.861 | 1.044 and 3.147 | – | 3.147, 25.496, and 1.305 |
Sensitivity (%) | 14 | 55 | 41 | 64 | 73 | 68 |
Specificity (%) | 97 | 97 | 97 | 97 | 97 | 97 |
True-positive tests (N) | 3 | 12 | 9 | 14 | 16 | 15 |
True-negative tests (N) | 30 | 30 | 29 | 29 | 29 | 29 |
False-positive tests (N) | 1 | 1 | 1 | 1 | 1 | 1 |
False-negative tests (N) | 19 | 10 | 13 | 8 | 6 | 7 |