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Fig. 2 | Biomarker Research

Fig. 2

From: Successful treatment of acute B lymphoblastic leukemia relapse in the skin and testicle by anti-CD19 CAR-T with IL-6 knocking down: a case report

Fig. 2

The summary of medication protocol, clinical and laboratory parameters relative to the timing of CART therapy. a, Chemotherapy for lymphpcyte depletion include fludarabine and cyclophosphamide. ssCART-19 cells were infused at a split-dose of 10% on day 01, 30% on day 02 and 60% on day 03(total 5 × 106/kg). b, Expressions of blasts in bone marrow and skin were detected by flow cytometry before and after ssCART-19 treatment. c, Testiclar size was measured by ultrasound respectively on the -5 day (before CAR-T), on + 4 day (during CAR-T), + 7 day (after CAR-T), + 37 day (before HSCT) and most recently (after HSCT). d, Related hematological toxicity after ssCART-19 treatment. e, The trends of the patient’s temperature in degrees centigrade (°C) per 24-h period. IL-6(pg/ml), IFN(pg/ml) and hsCRP(mg/l) concentrations are shown in lines during CART therapy. f, The expansion levels of ssCART-19 cells in the peripheral blood (PB) were monitored by qPCR on each day

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