Skip to main content
Fig. 3 | Biomarker Research

Fig. 3

From: Overexpressed immunoglobulin-like transcript (ILT) 4 in lung adenocarcinoma is correlated with immunosuppressive T cell subset infiltration and poor patient outcomes

Fig. 3

High ILT4 expression in tumor cells was correlated with reduced CD8+T cell and elevated Treg infiltration. a No significant correlation was found between ILT4 level and CD4+T cell proportion in LUAD tissues. The cutoff scores for ILT4-high and -low patients were defined as in Fig. 1c. b Patients in ILT4-high group had fewer CD8+T and more FOXP3+ T lymphocyte infiltration in TME compared with ILT4-low group by immunohistochemical assays. The typical images were presented. Scale bar: 20 μm. c & d Patients in ILT4-high group showed significantly decreased CD8+T (p < 0.001) and increased FOXP3+ T (p = 0.005) cell frequency in TILs. e & f The transcriptional expression level of ILT4 in LUAD tissues was positively correlated to Treg infiltration by analyses of GEO dataset (GSE 50081, n = 127) and TCGA database (n = 515). The correlation coefficient(r) was 0.24 and 0.50 respectively. g & h High ILT4 expression in tumor cells predicted decreased CD8+T (e) (p < 0.001 for cancer nest and p = 0.006 for stroma) and increased FOXP3+ T (f) (p = 0.004 for cancer nest and p = 0.037 for stroma) cell frequency in both cancer nest and stroma

Back to article page