Skip to main content
Fig. 2 | Biomarker Research

Fig. 2

From: Overexpressed immunoglobulin-like transcript (ILT) 4 in lung adenocarcinoma is correlated with immunosuppressive T cell subset infiltration and poor patient outcomes

Fig. 2

Overexpressed ILT4 in tumor cells was associated with decreased T cell infiltration in LUAD patients. a & b ILT4-high group displayed fewer CD3+T lymphocyte infiltration compared with the ILT4-low counterpart by immunohistochemical staining. a showed the typical images of ILT4 expression and infiltrating CD3+T cell density. Each paraffin-embedded tissue was sequentially sectioned for ILT4 or CD3 staining respectively. b showed the statistical result in all patients (p < 0.001). Scale bar:20 μm. c Low CD3+T cell frequency in TILs indicated poorer patient OS (p < 0.001). The cutoff value for high and low CD3 frequency were defined as ≥ median and < median respectively. d High ILT4 expression in tumor cells was correlated with reduced CD3+T cell proportion both in the cancer nest (p = 0.003) and stroma (p < 0.001). The cutoff scores for high and low ILT4 expression were the same as in Fig. 1c

Back to article page