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Fig. 1 | Biomarker Research

Fig. 1

From: Overexpressed immunoglobulin-like transcript (ILT) 4 in lung adenocarcinoma is correlated with immunosuppressive T cell subset infiltration and poor patient outcomes

Fig. 1

ILT4 expression in LUAD tissues predicted advanced diseases and poor patient survival. a & b ILT4 expression was significantly higher in tumor cells of LUAD tissues compared with that in adjacent normal tissues by immunohistochemical staining. a showed the typical images of ILT4 expression, brown granules were defined as positive staining. b showed the statistical results in all patients (p < 0.001). Scale bar:20 μm. c High ILT4 expression in LUAD tissues was correlated with advanced lymph node metastasis (p = 0.006) and TNM stages (p = 0.029). The cutoff scores for high and low ILT4 expression were ≥ 4 and < 4 respectively. d Patients in ILT4-high group showed markedly poorer OS compared with that in ILT4-low group (p < 0.001; HR = 2.22, 95%CI:1.43–3.45). According to the cutoff score, 102 patients were included in ILT4-high group and 114 in ILT4-low group. e ILT4 expression levels in human LUAD tissues were negatively associated with patient PFS and OS. Transcriptional expression levels of ILT4 and patient survival information were obtained from the GEO database. 720 and 461 LUAD patients were included for PFS and OS analysis, and the best cutoff values were auto-selected by the online tool of KM-plotter database (p = 0.032 for PFS and p = 8.9e-07 for OS)

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Biomarker Research

ISSN: 2050-7771

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