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Table 2 Univariable and multivariable Cox regression analyses in each data set

From: LncRNA profile study reveals a seven-lncRNA signature predicts the prognosis of patients with colorectal cancer

VariablesUnivariable modelaMultivariable modela
HR95% CI of HRP valuebHR95% CI of HRP valueb
GSE39582 training (N = 278)
 Seven-lncRNA risk score2.712.087–3.519< 0.0012.7492.111–3.579< 0.001
 Age0.9990.983–1.0140.8771.010.993–1.0270.261
 Gender1.4570.951–2.2330.0841.4280.925–2.2050.108
 TNM stage I1.00(referent)  1.00(referent)  
 TNM stage II10,245,8610.000-0.9945,864,6210.000-0.995
 TNM stage III16,355,0140.000-0.9937,823,0160.000-0.994
 TNM stage IV52,014,0590.000-0.99342,817,0260.000-0.994
GSE39582 validation (N = 274)
 Seven-lncRNA risk score1.9781.558–2.511< 0.0011.8751.435–2.449< 0.001
 Age10.984–1.0160.9770.9980.982–1.0150.839
 Gender1.1170.73–1.7090.6091.5590.996–2.4420.052
 TNM stage I1.00(referent)  1.00(referent)  
 TNM stage II4.420.598–32.6730.1453.2230.434–23.9440.253
 TNM stage III10.6441.465–77.3540.025.9970.808–44.5120.08
 TNM stage IV48.8476.533–365.212< 0.00140.8815.415–308.664< 0.001
Entire GSE39582 (N = 552)
 Seven-lncRNA risk score2.2631.907–2.685< 0.0012.2481.879–2.69< 0.001
 Age0.9990.988–1.0110.9271.0040.992–1.0150.538
 Gender1.2780.946–1.7260.1101.5361.132–2.0840.006
 TNM stage I1.00(referent)  1.00(referent)  
 TNM stage II7.4791.036–53.9840.0464.6520.642–33.6890.128
 TNM stage III14.371.999–103.2740.0086.90.95–50.1150.056
 TNM stage IV55.1897.558–402.996< 0.00142.1345.746–308.933< 0.001
GSE17538 validation (N = 200)
 Seven-lncRNA risk score1.9451.317–2.873< 0.0011.9051.206–3.0080.0057
 Age0.980.962–0.9990.0430.9890.968–1.010.312
 Gender0.750.441–1.2760.2890.8480.481–1.4930.567
 TNM stage I1.00(referent)  1.00(referent)  
 TNM stage II5.1770.668–40.1320.1164.3130.552–33.690.163
 TNM stage III10.2781.387–76.1720.0238.0641.076–60.4570.0423
 TNM stage IV49.4356.615–369.41< 0.00140.0525.299–302.762< 0.001
  1. Abbreviations: HR hazard ratio, CI confidence interval
  2. a In both univariable and multivariable Cox regression analyses, risk score and age were evaluated as continuous variables, and gender and TNM stage were evaluated as category variables
  3. bP < 0.05 was considered statistically significant in all analyses