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Table 2 Univariable and multivariable Cox regression analyses in each data set

From: LncRNA profile study reveals a seven-lncRNA signature predicts the prognosis of patients with colorectal cancer

Variables

Univariable modela

Multivariable modela

HR

95% CI of HR

P valueb

HR

95% CI of HR

P valueb

GSE39582 training (N = 278)

 Seven-lncRNA risk score

2.71

2.087–3.519

< 0.001

2.749

2.111–3.579

< 0.001

 Age

0.999

0.983–1.014

0.877

1.01

0.993–1.027

0.261

 Gender

1.457

0.951–2.233

0.084

1.428

0.925–2.205

0.108

 TNM stage I

1.00(referent)

  

1.00(referent)

  

 TNM stage II

10,245,861

0.000-

0.994

5,864,621

0.000-

0.995

 TNM stage III

16,355,014

0.000-

0.993

7,823,016

0.000-

0.994

 TNM stage IV

52,014,059

0.000-

0.993

42,817,026

0.000-

0.994

GSE39582 validation (N = 274)

 Seven-lncRNA risk score

1.978

1.558–2.511

< 0.001

1.875

1.435–2.449

< 0.001

 Age

1

0.984–1.016

0.977

0.998

0.982–1.015

0.839

 Gender

1.117

0.73–1.709

0.609

1.559

0.996–2.442

0.052

 TNM stage I

1.00(referent)

  

1.00(referent)

  

 TNM stage II

4.42

0.598–32.673

0.145

3.223

0.434–23.944

0.253

 TNM stage III

10.644

1.465–77.354

0.02

5.997

0.808–44.512

0.08

 TNM stage IV

48.847

6.533–365.212

< 0.001

40.881

5.415–308.664

< 0.001

Entire GSE39582 (N = 552)

 Seven-lncRNA risk score

2.263

1.907–2.685

< 0.001

2.248

1.879–2.69

< 0.001

 Age

0.999

0.988–1.011

0.927

1.004

0.992–1.015

0.538

 Gender

1.278

0.946–1.726

0.110

1.536

1.132–2.084

0.006

 TNM stage I

1.00(referent)

  

1.00(referent)

  

 TNM stage II

7.479

1.036–53.984

0.046

4.652

0.642–33.689

0.128

 TNM stage III

14.37

1.999–103.274

0.008

6.9

0.95–50.115

0.056

 TNM stage IV

55.189

7.558–402.996

< 0.001

42.134

5.746–308.933

< 0.001

GSE17538 validation (N = 200)

 Seven-lncRNA risk score

1.945

1.317–2.873

< 0.001

1.905

1.206–3.008

0.0057

 Age

0.98

0.962–0.999

0.043

0.989

0.968–1.01

0.312

 Gender

0.75

0.441–1.276

0.289

0.848

0.481–1.493

0.567

 TNM stage I

1.00(referent)

  

1.00(referent)

  

 TNM stage II

5.177

0.668–40.132

0.116

4.313

0.552–33.69

0.163

 TNM stage III

10.278

1.387–76.172

0.023

8.064

1.076–60.457

0.0423

 TNM stage IV

49.435

6.615–369.41

< 0.001

40.052

5.299–302.762

< 0.001

  1. Abbreviations: HR hazard ratio, CI confidence interval
  2. a In both univariable and multivariable Cox regression analyses, risk score and age were evaluated as continuous variables, and gender and TNM stage were evaluated as category variables
  3. bP < 0.05 was considered statistically significant in all analyses
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Biomarker Research

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