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Table 1 Glossary of TIS terminology

From: Using toponomics to characterize phenotypic diversity in alveolar macrophages from male mice treated with exogenous SP-A1

 Glossary of TIS terms
toponomethe spatial network of proteins within intact cells
TIStoponome imaging system – a robotically-controlled serial immunostainer
CMPcombinatorial molecular phenotype- a designation that summarizes the presence [1] or absence (0) of all markers in a given pixel (i.e. 1000110100011)
binarizationselecting of a threshold in aligned, background-subtracted images of immuno-fluorescence above which a marker is considered present [1] and below which it is absent (0)
.xml filea data file merging all of the binarization data from each marker into a single file and showing the CMP present in every pixel of an image
tripletsCMPs that are present in all three subjects in each experimental group in the 50 most frequent/abundant CMPs in the xml files.
2-of-3CMPs that are present in 2 out of the 3 subjects in each group in the 50 most frequent/abundant CMPs in the xml files