Fig. 8

CMP signatures selected by high levels of markers that distinguish between groups of KO and SP-A1 cells. Examples of these are shown in Panels A-D. In this Figure we selected cells by screening for high levels of particular markers at or above the limits listed in Table 4. The markers being used for the selection are indicated by the red arrows in each panel. The CMP summaries for each cell (see Fig. 6, Panel (A), bottom line) were screened to determine whether there were high levels of each marker (i.e. a marker that was present in a large number of the top 20 CMPs). Using the limits shown in Table 4, the cells with high levels of each marker were identified. In the key below the graphs, cells in the KO group are shown in red and SP-A1 cells are in black. Panel A depicts cells selected with markers 7 and 3 (9 of the 11 cells selected are in the KO group). Panel B shows cells selected with markers 5, 12, and 1 (8 of 10 are KO cells). Panel C depicts cells selected by markers 6 and 1 (9 of 11 are SP-A1 cells). Panel D shows cells selected by markers 2, 4, and 10 (12 of 13 are SP-A1 cells). Features (high or low levels of a given marker) that were not used in the selection, but are present in most, or all, members of a subgroup and may be useful for characterizing that subgroup are indicated with a dashed blue arrow