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Fig. 6 | Biomarker Research

Fig. 6

From: Using toponomics to characterize phenotypic diversity in alveolar macrophages from male mice treated with exogenous SP-A1

Fig. 6

Representative CMP summary. Panel (A) gives a binary representation (present = 1; absent = 0) of the CMP composition of each of the 20 most abundant CMPs for a representative cell (Cell #10 from the 5–27 sample; see also Figs. 4 and 5). Columns 0–12 are for each of the 13 markers analyzed. The bottom line in the table shows the total number of CMPs (out of the top 20) containing each of the 13 markers (as in Fig. 3, Panel B. For example, the total number of CMPs containing marker 1 is four. The column labeled “order” shows the order of abundance [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20] for the top 20 CMPs. The column marked “5-27 CMP #” gives the CMP number derived from the full image (Fig. 4) of the 5–27 sample (see Fig. 3, Panel A. Fig. 6, Panel (B) is organized as in Panel (A) and consists of data from the same cell used for Panel A except that it shows the number of pixels. In Panel (B) the number of pixels (last column) occupied by each CMP is recorded for each marker present in the top 20 CMPs. The total number of pixels occupied by each marker is given in the bottom line of Panel B. For example, the total number of pixels occupied by CMPs containing marker 2 is 2900. The columns labeled order and CMP# are as described with Panel (A) (above). Panel (C) provides a graphic “signature” of the binarized data in Panel (A), summed up in the bottom line of Panel (A) (highlighted gray and bold). Panel (D) depicts the summed data from Panel (B) (bottom line). The x-axis indicates the marker number (0–12). The y-axis in Panel (C) shows the number of CMPs containing each marker, and in Panel (D), the number of pixels occupied by each marker

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