Comprehensive analysis of peroxiredoxins expression profiles and prognostic values in breast cancer

Biomarker Research

Table 2 Association between prognostic value of PRDXs mRNA expression and different subclasses in BrCa

Subclasses	Cases	HR	95% CI	P value	Cases	HR	95% CI	P value
Subclasses	OS				RFS
PRDX1
Basal-like	241	0.66	0.40–1.09	0.104	618	1.02	0.80–1.32	0.850
Luminal A	611	1.52	1.06–2.17	0.022	1933	1.23	1.06–1.49	0.009
Luminal B	433	0.98	0.68–1.43	0.956	1149	1.20	0.99–1.46	0.060
HER2 positive	117	1.27	0.66–2.42	0.470	251	1.31	0.89–1.92	0.170
PRDX2
Basal-like	241	1.14	0.70–1.85	0.613	618	1.25	0.97–1.61	0.078
Luminal A	611	1.42	0.99–2.02	0.056	1933	1.23	1.04–1.46	0.016
Luminal B	433	0.99	0.67–1.44	0.960	1149	1.67	1.37–2.03	< 0.001
HER2 positive	117	0.93	0.49–1.77	0.821	251	1.24	0.85–1.83	0.264
PRDX3
Basal-like	241	0.77	0.47–1.26	0.299	618	0.77	0.60–1.00	0.046
Luminal A	611	0.74	0.52–1.05	0.090	1933	0.87	0.73–1.03	0.112
Luminal B	433	1.02	0.70–1.48	0.919	1149	1.17	0.96–1.41	0.115
HER2 positive	117	0.59	0.30–1.15	0.118	251	0.73	0.49–1.07	0.102
PRDX4
Basal-like	241	0.67	0.41–1.11	0.119	618	1.04	0.81–1.33	0.784
Luminal A	611	1.58	1.10–2.27	0.012	1933	1.56	1.31–1.85	< 0.001
Luminal B	433	1.55	1.06–2.27	0.023	1149	1.56	1.28–1.89	< 0.001
HER2 positive	117	0.41	0.20–0.83	0.010	251	0.83	0.57–1.23	0.358
PRDX5
Basal-like	153	1.09	0.58–2.06	0.790	360	1.71	1.23–2.37	0.001
Luminal A	271	1.09	0.66–1.81	0.725	841	1.19	0.93–1.53	0.164
Luminal B	129	0.58	0.29–1.15	0.117	407	0.95	0.70–1.29	0.752
HER2 positive	73	1.59	0.71–3.54	0.253	156	1.34	0.85–2.11	0.213
PRDX6
Basal-like	241	1.08	0.66–1.76	0.761	618	1.01	0.78–1.29	0.963
Luminal A	611	1.49	1.04–2.13	0.027	1933	1.29	1.08–1.53	0.004
Luminal B	433	0.95	0.65–1.37	0.771	1149	1.27	1.05–1.54	0.015
HER2 positive	117	0.87	0.46–1.66	0.675	251	0.93	0.63–1.36	0.708

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