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Fig. 5 | Biomarker Research

Fig. 5

From: DLGAP1 directs megakaryocytic growth and differentiation in an MPL dependent manner in hematopoietic cells

Fig. 5

DLGAP1 effects on megakaryocytic polyploidization processes. a Immunofluorescent microscopy of plain K562 and K562 cells driven by MPL signaling overexpressing GFP-DLGAP1 and GFP-Tr-DLGAP1 treated for 3 and 7 days with SU6656. GFP is fluorescing green, alpha-Tubulin was stained red specific antibody and DNA was stained blue with DAPI. b Immunofluorescent microscopy of HEL cells driven into megakaryocytic differentiation by 6 days treatment with Nocodazole and PMA. Cells were grown in medium supplemented with empty vector, scrambled shRNA and specific DLGAP1 shRNA as indicated. Native DLGAP1 was stained green with anti-DLGAP1 antibody, shRNA vectors expressed RFP fluorescing red and DNA was stained blue with DAPI

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